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    Prkcsh PRKCSH beta subunit of glucosidase II [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300445, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prkcshprovided by RGD
    Official Full Name
    PRKCSH beta subunit of glucosidase IIprovided by RGD
    Primary source
    RGD:1309628
    See related
    EnsemblRapid:ENSRNOG00000013360 AllianceGenome:RGD:1309628
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including calcium ion binding activity; protein kinase C binding activity; and transmembrane transporter binding activity. Predicted to be involved in N-glycan processing and liver development. Predicted to act upstream of or within in utero embryonic development and negative regulation of neuron projection development. Predicted to be located in endoplasmic reticulum. Predicted to be part of glucosidase II complex. Human ortholog(s) of this gene implicated in liver disease and polycystic liver disease 1. Orthologous to human PRKCSH (PRKCSH beta subunit of glucosidase II). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 427.8), Adrenal (RPKM 359.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prkcsh in Genome Data Viewer
    Location:
    8q13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28810836..28822503)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20534787..20546493)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (23014802..23026507)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ral guanine nucleotide dissociation stimulator like 3 Neighboring gene uncharacterized LOC134480147 Neighboring gene outer dynein arm docking complex subunit 3 Neighboring gene ELAV like RNA binding protein 3 Neighboring gene zinc finger protein 653 Neighboring gene uncharacterized LOC120094091

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hepatocystin contributes to interferon-mediated antiviral response to hepatitis B virus by regulating hepatocyte nuclear factor 4α. Shin GC, et al. Biochim Biophys Acta, 2014 Sep. PMID 24769044
    2. Abnormal hepatocystin caused by truncating PRKCSH mutations leads to autosomal dominant polycystic liver disease. Drenth JP, et al. Hepatology, 2004 Apr. PMID 15057895
    3. Domain-specific gene activation by parathyroid hormone in osteoblastic ROS17/2.8 cells. Hollnagel A, et al. J Biol Chem, 1996 Sep 6. PMID 8702988
    4. A novel RNA binding protein that interacts with NMDA R1 mRNA: regulation by ethanol. Anji A, et al. Eur J Neurosci, 2006 May. PMID 16706842
    5. Mutations in PRKCSH cause isolated autosomal dominant polycystic liver disease. Li A, et al. Am J Hum Genet, 2003 Mar. PMID 12529853, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-glycan processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in liver development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within liver development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nitrogen cycle metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nitrogen cycle metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of glucosidase II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glucosidase II complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    glucosidase 2 subunit beta
    Names
    protein kinase C substrate 80K-H
    NP_001100276.1
    XP_006242695.1
    XP_006242696.1
    XP_063121136.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106806.2 → NP_001100276.1  glucosidase 2 subunit beta precursor

      See identical proteins and their annotated locations for NP_001100276.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161987
      UniProtKB/TrEMBL
      A0A8I6ADW9, B1WC34, F7EM53
      Related
      ENSRNOP00000101711.1, ENSRNOT00000166669.1
      Conserved Domains (3) summary
      smart00192
      Location:36 → 63
      LDLa; Low-density lipoprotein receptor domain class A
      cl06793
      Location:377 → 505
      PRKCSH; Glucosidase II beta subunit-like protein
      cl21478
      Location:113 → 255
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28810836..28822503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242634.2 → XP_006242696.1  glucosidase 2 subunit beta isoform X2

      UniProtKB/TrEMBL
      A6JNX3
      Related
      ENSRNOP00000018009.6, ENSRNOT00000018009.8
      Conserved Domains (3) summary
      pfam12999
      Location:20 → 162
      PRKCSH-like; Glucosidase II beta subunit-like
      cl06793
      Location:370 → 498
      PRKCSH; Glucosidase II beta subunit-like protein
      cl21478
      Location:113 → 255
      ATP-synt_B; ATP synthase B/B' CF(0)

    2. XM_063265066.1 → XP_063121136.1  glucosidase 2 subunit beta isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADW9, B1WC34, F7EM53
      Related
      ENSRNOP00000086800.2, ENSRNOT00000103948.2

    3. XM_006242633.5 → XP_006242695.1  glucosidase 2 subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006242695.1

      UniProtKB/TrEMBL
      A0A8I6ADW9, B1WC34, F7EM53
      Conserved Domains (3) summary
      smart00192
      Location:36 → 63
      LDLa; Low-density lipoprotein receptor domain class A
      cl06793
      Location:377 → 505
      PRKCSH; Glucosidase II beta subunit-like protein
      cl21478
      Location:113 → 255
      ATP-synt_B; ATP synthase B/B' CF(0)
    Nucleotide Protein Strain
    Heading Accession and Version

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