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    Slc37a4 solute carrier family 37 member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29573, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc37a4provided by RGD
    Official Full Name
    solute carrier family 37 member 4provided by RGD
    Primary source
    RGD:62066
    See related
    EnsemblRapid:ENSRNOG00000011361 AllianceGenome:RGD:62066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    G6pt1
    Summary
    Enables glucose-6-phosphate transmembrane transporter activity. Involved in several processes, including glucose-6-phosphate transport; response to glucose; and response to nutrient. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II; glycogen storage disease Ib; and glycogen storage disease Ic. Orthologous to human SLC37A4 (solute carrier family 37 member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 824.8), Liver (RPKM 684.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc37a4 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53619952..53626110)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44723216..44729301)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48716914..48723024)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene VPS11 core subunit of CORVET and HOPS complexes Neighboring gene hypoxia up-regulated 1 Neighboring gene trafficking protein particle complex subunit 4 Neighboring gene ribosomal protein s25 Neighboring gene centrosomal AT-AC splicing factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effects of fasting and refeeding on the activity of hepatic glucose-6-phosphatase in rats. Khan A, et al. Acta Physiol Scand, 1985 Aug. PMID 2996302
    2. Plasma glucose levels are reduced in rats and mice treated with an inhibitor of glucose-6-phosphate translocase. Parker JC, et al. Diabetes, 1998 Oct. PMID 9753303
    3. Diabetes affects similarly the catalytic subunit and putative glucose-6-phosphate translocase of glucose-6-phosphatase. Li Y, et al. J Biol Chem, 1999 Nov 26. PMID 10567346
    4. Evidence for glucose-6-phosphate transport in rat liver microsomes. Gerin I, et al. FEBS Lett, 2002 Apr 24. PMID 12062448
    5. Human variant glucose-6-phosphate transporter is active in microsomal transport. Lin B, et al. Hum Genet, 2000 Nov. PMID 11140953

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. adipocytes are equipped with a functional G6PT-hexose-6-phosphate dehydrogenase-11beta-hydroxysteroid dehydrogenase type 1 system
      Title: The glucose-6-phosphate transporter-hexose-6-phosphate dehydrogenase-11beta-hydroxysteroid dehydrogenase type 1 system of the adipose tissue.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glucose 6-phosphate:phosphate antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose 6-phosphate:phosphate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucose-6-phosphate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glucose-6-phosphate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose-6-phosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose-6-phosphate transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glucose-6-phosphate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose-6-phosphate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycogen metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lactate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myeloid progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neutrophil homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within respiratory burst ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glucose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glucose-6-phosphate exchanger SLC37A4
    Names
    glucose-6-phosphatase, transport protein 1
    glucose-6-phosphate translocase
    solute carrier family 37 (glucose-6-phosphate transporter), member 4
    solute carrier family 37 (glycerol-6-phosphate transporter), member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416484.1 → NP_001403413.1  glucose-6-phosphate exchanger SLC37A4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      Q6IRK4

    2. NM_001416485.1 → NP_001403414.1  glucose-6-phosphate exchanger SLC37A4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      Q6IRK4
      Related
      ENSRNOP00000015810.5, ENSRNOT00000015810.7

    3. NM_031589.2 → NP_113777.2  glucose-6-phosphate exchanger SLC37A4

      See identical proteins and their annotated locations for NP_113777.2

      Status: PROVISIONAL

      Source sequence(s)
      BC070889
      UniProtKB/TrEMBL
      Q6IRK4, Q9Z296
      Conserved Domains (1) summary
      cd17343
      Location:10 → 417
      MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      53619952..53626110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265025.1 → XP_063121095.1  glucose-6-phosphate exchanger SLC37A4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTY3

    2. XM_063265026.1 → XP_063121096.1  glucose-6-phosphate exchanger SLC37A4 isoform X3

      UniProtKB/TrEMBL
      F7EWB7

    3. XM_063265022.1 → XP_063121092.1  glucose-6-phosphate exchanger SLC37A4 isoform X2

    4. XM_063265021.1 → XP_063121091.1  glucose-6-phosphate exchanger SLC37A4 isoform X2

    5. XM_008766151.4 → XP_008764373.3  glucose-6-phosphate exchanger SLC37A4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTY3
      Related
      ENSRNOP00000068889.2, ENSRNOT00000089763.3

    6. XM_039080967.2 → XP_038936895.2  glucose-6-phosphate exchanger SLC37A4 isoform X3

      UniProtKB/TrEMBL
      F7EWB7

    7. XM_063265020.1 → XP_063121090.1  glucose-6-phosphate exchanger SLC37A4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTY3

    8. XM_063265027.1 → XP_063121097.1  glucose-6-phosphate exchanger SLC37A4 isoform X3

      UniProtKB/TrEMBL
      F7EWB7

    9. XM_063265023.1 → XP_063121093.1  glucose-6-phosphate exchanger SLC37A4 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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