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    Elk3 ETS transcription factor ELK3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362871, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Elk3provided by RGD
    Official Full Name
    ETS transcription factor ELK3provided by RGD
    Primary source
    RGD:1307764
    See related
    EnsemblRapid:ENSRNOG00000004367 AllianceGenome:RGD:1307764
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within angiogenesis; regulation of DNA-templated transcription; and wound healing. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ELK3 (ETS transcription factor ELK3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 206.4), Heart (RPKM 123.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elk3 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (29655676..29718163, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (27768582..27831088, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (34086213..34149601, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093552 Neighboring gene cilia and flagella associated protein 54 Neighboring gene uncharacterized LOC134479658 Neighboring gene cyclin-dependent kinase 17 Neighboring gene uncharacterized LOC102548950 Neighboring gene uncharacterized LOC134479659

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The transcription factor Net regulates the angiogenic switch. Zheng H, et al. Genes Dev, 2003 Sep 15. PMID 12975317, Free PMC Article
    2. Transcriptional regulation of the cytosolic chaperonin theta subunit gene, Cctq, by Ets domain transcription factors Elk-1, Sap-1a, and Net in the absence of serum response factor. Yamazaki Y, et al. J Biol Chem, 2003 Aug 15. PMID 12788937
    3. The expression of ELK transcription factors in adult DRG: Novel isoforms, antisense transcripts and upregulation by nerve damage. Kerr N, et al. Mol Cell Neurosci, 2010 Jun. PMID 20304071, Free PMC Article
    4. Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure. Gupta M, et al. J Biol Chem, 2003 Nov 7. PMID 12933792
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables purine-rich negative regulatory element binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ETS domain-containing protein Elk-3
    Names
    ELK3, ETS transcription factor
    ELK3, ETS-domain protein
    ELK3, member of ETS oncogene family

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108743.1 → NP_001102213.1  ETS domain-containing protein Elk-3

      See identical proteins and their annotated locations for NP_001102213.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473960
      UniProtKB/TrEMBL
      A0A8I6AFZ2, A6IFX9, D4A9V6
      Related
      ENSRNOP00000005911.5, ENSRNOT00000005911.8
      Conserved Domains (1) summary
      smart00413
      Location:5 → 89
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      29655676..29718163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241265.5 → XP_006241327.1  ETS domain-containing protein Elk-3 isoform X1

      See identical proteins and their annotated locations for XP_006241327.1

      UniProtKB/TrEMBL
      A0A8I6AFZ2, A6IFX9, D4A9V6
      Conserved Domains (1) summary
      smart00413
      Location:5 → 89
      ETS; erythroblast transformation specific domain

    2. XM_063263770.1 → XP_063119840.1  ETS domain-containing protein Elk-3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ADA1, A6IFY0

    3. XM_063263769.1 → XP_063119839.1  ETS domain-containing protein Elk-3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AFZ2

    4. XM_063263771.1 → XP_063119841.1  ETS domain-containing protein Elk-3 isoform X4

      UniProtKB/TrEMBL
      A6IFY1
    Nucleotide Protein Strain
    Heading Accession and Version

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