Sun2 Sad1 and UNC84 domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sun2provided by RGD
Official Full Name: Sad1 and UNC84 domain containing 2provided by RGD
Primary source: RGD:1563141
See related: EnsemblRapid:ENSRNOG00000015177 AllianceGenome:RGD:1563141
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Unc84b; RGD1563141
Summary: Predicted to enable cytoskeleton-nuclear membrane anchor activity; identical protein binding activity; and lamin binding activity. Predicted to be involved in several processes, including centrosome localization; nuclear matrix anchoring at nuclear membrane; and nuclear migration. Predicted to be located in chromosome, telomeric region; condensed nuclear chromosome; and nuclear inner membrane. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in nuclear envelope. Orthologous to human SUN2 (Sad1 and UNC84 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 326.6), Muscle (RPKM 280.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (113155766..113172950, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (111275374..111292565, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (120950391..120967583, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sun2 is part of a membrane-spanning fibrillar complex that interconnects attached telomeres with cytoplasmic structures.
Title: Transmembrane protein Sun2 is involved in tethering mammalian meiotic telomeres to the nuclear envelope.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytoskeleton-nuclear membrane anchor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lamin binding	ISO Inferred from Sequence Orthology more info
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in centrosome localization	ISO Inferred from Sequence Orthology more info
involved_in nuclear matrix anchoring at nuclear membrane	ISO Inferred from Sequence Orthology more info
involved_in nuclear migration along microfilament	ISO Inferred from Sequence Orthology more info
involved_in nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
part_of meiotic nuclear membrane microtubule tethering complex	IBA Inferred from Biological aspect of Ancestor more info
part_of meiotic nuclear membrane microtubule tethering complex	ISO Inferred from Sequence Orthology more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear inner membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SUN domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427688.1 → NP_001414617.1 SUN domain-containing protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6A6J5, A6HST7

Related

ENSRNOP00000088618.1, ENSRNOT00000110877.2
NM_001427689.1 → NP_001414618.1 SUN domain-containing protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6A6J5, D3ZTT7
NM_001427690.1 → NP_001414619.1 SUN domain-containing protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6A6J5