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    Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314961, updated on 9-Dec-2024

    Summary

    Official Symbol
    Asap1provided by RGD
    Official Full Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domain 1provided by RGD
    Primary source
    RGD:1307379
    See related
    EnsemblRapid:ENSRNOG00000058733 AllianceGenome:RGD:1307379
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DEF-1; Ddef1
    Summary
    Predicted to enable GTPase activator activity and phospholipid binding activity. Predicted to be involved in several processes, including positive regulation of membrane tubulation; protein localization to cilium; and regulation of postsynapse organization. Predicted to act upstream of or within negative regulation of dendritic spine development. Predicted to be located in Golgi membrane; dendritic spine; and trans-Golgi network membrane. Predicted to be active in glutamatergic synapse and podosome. Orthologous to human ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 139.2), Brain (RPKM 97.8) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Asap1 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (97675354..97982523, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (95786130..96093111, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (104670076..104951090, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093676 Neighboring gene uncharacterized LOC134479920 Neighboring gene CYFIP related Rac1 interactor B Neighboring gene uncharacterized LOC134479921 Neighboring gene adenylate cyclase 8 Neighboring gene proteasome 20S subunit beta 3 like 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylserine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of dendritic spine development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of membrane tubulation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cilium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in podosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
    Names
    130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein
    130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein
    ADP-ribosylation factor-directed GTPase-activating protein 1
    ARF GTPase-activating protein 1
    PIP2-dependent ARF1 GAP
    development and differentiation enhancing
    development and differentiation-enhancing factor 1
    differentiation-enhancing factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044245.2NP_001037710.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q1AAU4, Q1AAU5, Q1AAU6
      Related
      ENSRNOP00000072909.3, ENSRNOT00000079981.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      97675354..97982523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079180.2XP_038935108.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7

      UniProtKB/Swiss-Prot
      Q1AAU4, Q1AAU5, Q1AAU6
      Conserved Domains (7) summary
      cd07641
      Location:54268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:10171073
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:727979
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:316422
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:601634
      ANK; ANK repeat [structural motif]
      cd08848
      Location:437558
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:605677
      Ank_2; Ankyrin repeats (3 copies)
    2. XM_039079174.2XP_038935102.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q1AAU4, Q1AAU5, Q1AAU6
      Conserved Domains (7) summary
      cd07641
      Location:54268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:10741130
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:7241036
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:316422
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:601634
      ANK; ANK repeat [structural motif]
      cd08848
      Location:437558
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:605677
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_039079177.2XP_038935105.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X4

      UniProtKB/Swiss-Prot
      Q1AAU4, Q1AAU5, Q1AAU6
      Related
      ENSRNOP00000071134.3, ENSRNOT00000085650.3
      Conserved Domains (7) summary
      cd07641
      Location:54268
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:10291085
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:739991
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:328434
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:613646
      ANK; ANK repeat [structural motif]
      cd08848
      Location:449570
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:617689
      Ank_2; Ankyrin repeats (3 copies)
    4. XM_063263529.1XP_063119599.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q1AAU4, Q1AAU5, Q1AAU6
    5. XM_063263531.1XP_063119601.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZYZ1
      Related
      ENSRNOP00000070164.3, ENSRNOT00000079524.3
    6. XM_039079178.2XP_038935106.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5

      UniProtKB/Swiss-Prot
      Q1AAU4, Q1AAU5, Q1AAU6
      Conserved Domains (7) summary
      cd07641
      Location:34248
      BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
      cd11965
      Location:10541110
      SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
      PHA03247
      Location:7041016
      PHA03247; large tegument protein UL36; Provisional
      cd13251
      Location:296402
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:581614
      ANK; ANK repeat [structural motif]
      cd08848
      Location:417538
      ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
      pfam12796
      Location:585657
      Ank_2; Ankyrin repeats (3 copies)
    7. XM_063263530.1XP_063119600.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q1AAU4, Q1AAU5, Q1AAU6
      UniProtKB/TrEMBL
      A0A8I6GFT7
      Related
      ENSRNOP00000084328.2, ENSRNOT00000107914.2
    8. XM_063263533.1XP_063119603.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X8

      UniProtKB/Swiss-Prot
      Q1AAU4, Q1AAU5, Q1AAU6
      UniProtKB/TrEMBL
      A0A0G2JZQ0
    9. XM_063263535.1XP_063119605.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JX76
    10. XM_063263534.1XP_063119604.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A0G2JX76
    11. XM_063263536.1XP_063119606.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

    RNA

    1. XR_005486633.2 RNA Sequence