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    Plk5 polo-like kinase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314627, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plk5provided by RGD
    Official Full Name
    polo-like kinase 5provided by RGD
    Primary source
    RGD:1305038
    See related
    EnsemblRapid:ENSRNOG00000034102 AllianceGenome:RGD:1305038
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Plk5p
    Summary
    Predicted to enable ATP binding activity. Predicted to be involved in several processes, including defense response to tumor cell; mitotic spindle organization; and regulation of G1/S transition of mitotic cell cycle. Predicted to be located in nucleolus. Predicted to be active in several cellular components, including kinetochore; microtubule cytoskeleton; and nucleus. Orthologous to human PLK5 (polo like kinase 5 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 26.1), Thymus (RPKM 19.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plk5 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9997453..10006959, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9346777..9367923, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12212910..12234253, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene methyl-CpG binding domain protein 3 Neighboring gene mex-3 RNA binding family member D Neighboring gene ADAMTS-like 5 Neighboring gene receptor accessory protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. de Cárcer G, et al. Mol Cell Biol, 2011 Mar. PMID 21245385, Free PMC Article
    2. The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus. Andrysik Z, et al. Nucleic Acids Res, 2010 May. PMID 20100802, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inactive serine/threonine-protein kinase PLK5
    Names
    polo-like kinase 5 pseudogene
    serine/threonine-protein kinase PLK5
    NP_001164028.1
    XP_006240983.1
    XP_006240984.1
    XP_006240985.1
    XP_006240987.1
    XP_008763320.1
    XP_008763321.1
    XP_038934931.1
    XP_038934933.1
    XP_063119487.1
    XP_063119488.1
    XP_063119489.1
    XP_063119490.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170557.1 → NP_001164028.1  inactive serine/threonine-protein kinase PLK5

      See identical proteins and their annotated locations for NP_001164028.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474029
      UniProtKB/TrEMBL
      A6K8L7, A6K8L8
      Conserved Domains (3) summary
      smart00220
      Location:27 → 279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13118
      Location:410 → 497
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd14099
      Location:25 → 279
      STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9997453..10006959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240922.5 → XP_006240984.1  inactive serine/threonine-protein kinase PLK5 isoform X2

      UniProtKB/TrEMBL
      A6K8L8
      Related
      ENSRNOP00000107666.1, ENSRNOT00000158969.1
      Conserved Domains (3) summary
      smart00220
      Location:27 → 279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13118
      Location:410 → 497
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd14099
      Location:25 → 279
      STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases

    2. XM_008765098.4 → XP_008763320.1  inactive serine/threonine-protein kinase PLK5 isoform X3

      Conserved Domains (3) summary
      smart00220
      Location:27 → 279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13118
      Location:429 → 516
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd14099
      Location:25 → 279
      STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases

    3. XM_063263417.1 → XP_063119487.1  inactive serine/threonine-protein kinase PLK5 isoform X6

    4. XM_006240923.5 → XP_006240985.1  inactive serine/threonine-protein kinase PLK5 isoform X4

      UniProtKB/TrEMBL
      A6K8L8
      Conserved Domains (3) summary
      smart00220
      Location:27 → 240
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13118
      Location:390 → 477
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cl21453
      Location:25 → 240
      PKc_like; Protein Kinases, catalytic domain

    5. XM_006240921.5 → XP_006240983.1  inactive serine/threonine-protein kinase PLK5 isoform X1

      UniProtKB/TrEMBL
      D3ZY07
      Related
      ENSRNOP00000051194.5, ENSRNOT00000042204.6
      Conserved Domains (3) summary
      smart00220
      Location:27 → 279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13118
      Location:429 → 516
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd14099
      Location:25 → 279
      STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases

    6. XM_063263418.1 → XP_063119488.1  inactive serine/threonine-protein kinase PLK5 isoform X7

      UniProtKB/TrEMBL
      A6K8L8
      Related
      ENSRNOP00000100195.1, ENSRNOT00000146724.1

    7. XM_039079003.2 → XP_038934931.1  inactive serine/threonine-protein kinase PLK5 isoform X8

      UniProtKB/TrEMBL
      A6K8L8
      Conserved Domains (2) summary
      cd13118
      Location:344 → 431
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cl21453
      Location:1 → 194
      PKc_like; Protein Kinases, catalytic domain

    8. XM_008765099.4 → XP_008763321.1  inactive serine/threonine-protein kinase PLK5 isoform X5

      See identical proteins and their annotated locations for XP_008763321.1

      UniProtKB/TrEMBL
      A6K8L8
      Conserved Domains (3) summary
      smart00220
      Location:2 → 233
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13118
      Location:383 → 470
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cl21453
      Location:1 → 233
      PKc_like; Protein Kinases, catalytic domain

    9. XM_039079005.2 → XP_038934933.1  inactive serine/threonine-protein kinase PLK5 isoform X10

      Conserved Domains (1) summary
      cd13118
      Location:139 → 226
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

    10. XM_063263419.1 → XP_063119489.1  inactive serine/threonine-protein kinase PLK5 isoform X11

    11. XM_006240925.5 → XP_006240987.1  inactive serine/threonine-protein kinase PLK5 isoform X9

      See identical proteins and their annotated locations for XP_006240987.1

      Conserved Domains (3) summary
      smart00220
      Location:27 → 279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13118
      Location:429 → 467
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd14099
      Location:25 → 279
      STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases

    12. XM_063263420.1 → XP_063119490.1  inactive serine/threonine-protein kinase PLK5 isoform X12

    RNA

    1. XR_355241.5 RNA Sequence

    2. XR_355240.5 RNA Sequence

    3. XR_005486602.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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