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    Cyrib CYFIP related Rac1 interactor B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299909, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cyribprovided by RGD
    Official Full Name
    CYFIP related Rac1 interactor Bprovided by RGD
    Primary source
    RGD:1307697
    See related
    EnsemblRapid:ENSRNOG00000061246 AllianceGenome:RGD:1307697
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam49b; RGD1307697
    Summary
    Predicted to enable MHC class Ib protein binding, via antigen binding activity groove and small GTPase binding activity. Predicted to be involved in several processes, including positive regulation of memory T cell activation; positive regulation of type II interferon production; and regulation of organelle organization. Predicted to be located in cilium and mitochondrion. Orthologous to human CYRIB (CYFIP related Rac1 interactor B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 220.8), Thymus (RPKM 208.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cyrib in Genome Data Viewer
    Location:
    7q33
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (97524941..97649846, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (95633876..95760588, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (104514566..104641875, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC120093676 Neighboring gene gasdermin D like 1 Neighboring gene gasdermin C Neighboring gene uncharacterized LOC134479920 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Neighboring gene uncharacterized LOC134479921 Neighboring gene adenylate cyclase 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Fort L, et al. Nat Cell Biol, 2018 Oct. PMID 30250061, Free PMC Article
    2. FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis. Chattaragada MS, et al. Oncogene, 2018 Feb 8. PMID 29059164, Free PMC Article
    3. CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection. Yuki KE, et al. Nat Microbiol, 2019 Sep. PMID 31285585
    4. Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum. Nagarajan NA, et al. Nat Immunol, 2012 Apr 22. PMID 22522492, Free PMC Article
    5. Proteomic analysis of mammalian primary cilia. Ishikawa H, et al. Curr Biol, 2012 Mar 6. PMID 22326026, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MHC class Ib protein binding, via antigen binding groove ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to molecule of bacterial origin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of memory T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CYFIP-related Rac1 interactor B
    Names
    family with sequence similarity 49, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126267.2 → NP_001119739.1  CYFIP-related Rac1 interactor B

      See identical proteins and their annotated locations for NP_001119739.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166469
      UniProtKB/TrEMBL
      A0A0G2K4V6, B2GUZ9
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      97524941..97649846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078775.2 → XP_038934703.1  CYFIP-related Rac1 interactor B isoform X3

      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    2. XM_039078773.2 → XP_038934701.1  CYFIP-related Rac1 interactor B isoform X3

      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    3. XM_008765501.4 → XP_008763723.1  CYFIP-related Rac1 interactor B isoform X1

      See identical proteins and their annotated locations for XP_008763723.1

      UniProtKB/TrEMBL
      A0A0G2JXI6, A0A0G2K4V6, A6HRP7
      Related
      ENSRNOP00000073189.3, ENSRNOT00000078116.3
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    4. XM_039078771.2 → XP_038934699.1  CYFIP-related Rac1 interactor B isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4V6, B2GUZ9
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    5. XM_017594751.3 → XP_017450240.1  CYFIP-related Rac1 interactor B isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4V6, B2GUZ9
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    6. XM_039078774.2 → XP_038934702.1  CYFIP-related Rac1 interactor B isoform X3

      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    7. XM_006241633.2 → XP_006241695.1  CYFIP-related Rac1 interactor B isoform X2

      See identical proteins and their annotated locations for XP_006241695.1

      UniProtKB/TrEMBL
      A0A0G2K4V6, B2GUZ9
      Related
      ENSRNOP00000070286.3, ENSRNOT00000090784.3
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    8. XM_006241635.5 → XP_006241697.1  CYFIP-related Rac1 interactor B isoform X1

      See identical proteins and their annotated locations for XP_006241697.1

      UniProtKB/TrEMBL
      A0A0G2JXI6, A0A0G2K4V6, A6HRP7
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    9. XM_063263248.1 → XP_063119318.1  CYFIP-related Rac1 interactor B isoform X2

      UniProtKB/TrEMBL
      B2GUZ9
    Nucleotide Protein Strain
    Heading Accession and Version

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