Asap2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asap2provided by RGD
Official Full Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 2provided by RGD
Primary source: RGD:1305263
See related: EnsemblRapid:ENSRNOG00000061519 AllianceGenome:RGD:1305263
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ddef2
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in positive regulation of GTPase activity. Predicted to be located in cytosol and plasma membrane. Orthologous to human ASAP2 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 61.2), Lung (RPKM 44.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (46386605..46549669)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (40658201..40821017)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (43231178..43348606)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc63b12.x1 (e-PCR)
- UniSTS:203953

BF388376 (e-PCR)
- UniSTS:244924

BE116838 (e-PCR)
- UniSTS:248549

BF405170 (e-PCR)
- UniSTS:247807

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

Names: development and differentiation enhancing factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108704.3 → NP_001102174.2 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I5ZL33

Related

ENSRNOP00000078581.2, ENSRNOT00000101416.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

46386605..46549669

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039113150.2 → XP_038969078.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X6

Conserved Domains (1) summary

cl12013
Location:34 → 67

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_063262069.1 → XP_063118139.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1
XM_039113144.2 → XP_038969072.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZRL8, A0A8I6GLF1

Related

ENSRNOP00000096020.2, ENSRNOT00000119000.2

Conserved Domains (6) summary

cd07642
Location:34 → 248

BAR_ASAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 2

cd11966
Location:942 → 997

SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2

cd13251
Location:297 → 403

PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain

sd00045
Location:586 → 618

ANK; ANK repeat [structural motif]

cd08849
Location:419 → 541

ArfGap_ASAP2; ArfGAP domain of ASAP2 (ArfGAP2 with SH3 domain, ANK repeat and PH domain-containing protein 2)

pfam12796
Location:589 → 675

Ank_2; Ankyrin repeats (3 copies)
XM_063262070.1 → XP_063118140.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X3
XM_063262071.1 → XP_063118141.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X4
XM_063262072.1 → XP_063118142.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X5