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    Mdga2 MAM domain containing glycosylphosphatidylinositol anchor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314180, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mdga2provided by RGD
    Official Full Name
    MAM domain containing glycosylphosphatidylinositol anchor 2provided by RGD
    Primary source
    RGD:735131
    See related
    EnsemblRapid:ENSRNOG00000000618 AllianceGenome:RGD:735131
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mamdc1
    Summary
    Involved in regulation of synapse maturation and spinal cord motor neuron differentiation. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 58.5), Testes (RPKM 14.2) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mdga2 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (90482687..91346784, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (84746422..85608640, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (88442620..89292454, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479393 Neighboring gene U2 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134479395 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene mitochondrial transcription termination factor 1, pseudogene 4 Neighboring gene small nucleolar RNA, H/ACA box 32 Neighboring gene U2 spliceosomal RNA Neighboring gene ribosomal protein L11, pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior. Toledo A, et al. Elife, 2022 May 9. PMID 35532105, Free PMC Article
    2. Altered Cortical Dynamics and Cognitive Function upon Haploinsufficiency of the Autism-Linked Excitatory Synaptic Suppressor MDGA2. Connor SA, et al. Neuron, 2016 Sep 7. PMID 27608760
    3. A chimaeric mouse model for autosomal-dominant polycystic kidney disease. Boulter CA, et al. Contrib Nephrol, 1992. PMID 1633717
    4. Laf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex. Moore JM, et al. PLoS One, 2014. PMID 25162227, Free PMC Article
    5. MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development. Lee K, et al. Proc Natl Acad Sci U S A, 2013 Jan 2. PMID 23248271, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development.
      Title: MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within motor behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pattern specification process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synapse maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic membrane adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spinal cord motor neuron differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MAM domain-containing glycosylphosphatidylinositol anchor protein 2
    Names
    MAM domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199269.1 → NP_954890.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 2 precursor

      See identical proteins and their annotated locations for NP_954890.1

      Status: PROVISIONAL

      Source sequence(s)
      AY371924
      UniProtKB/Swiss-Prot
      P60756
      UniProtKB/TrEMBL
      A0A0H2UH93
      Related
      ENSRNOP00000000767.6, ENSRNOT00000000767.7
      Conserved Domains (6) summary
      cd06263
      Location:741 → 912
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      cd00096
      Location:355 → 427
      Ig; Immunoglobulin domain
      smart00408
      Location:256 → 317
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:48 → 128
      IG_like; Immunoglobulin like
      pfam00629
      Location:741 → 914
      MAM; MAM domain, meprin/A5/mu
      pfam13895
      Location:543 → 618
      Ig_2; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      90482687..91346784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764688.4 → XP_008762910.2  MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UH93, A0A8I6AD32
      Related
      ENSRNOP00000092110.1, ENSRNOT00000116494.2
      Conserved Domains (6) summary
      smart00408
      Location:256 → 317
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:48 → 128
      IG; Immunoglobulin
      pfam00629
      Location:748 → 920
      MAM; MAM domain, meprin/A5/mu
      pfam13927
      Location:441 → 518
      Ig_3; Immunoglobulin domain
      cd00096
      Location:461 → 468
      Ig; Ig strand B [structural motif]
      cl11960
      Location:349 → 424
      Ig; Immunoglobulin domain

    2. XM_039112248.2 → XP_038968176.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UH93
      Related
      ENSRNOP00000100044.1, ENSRNOT00000153837.1
      Conserved Domains (6) summary
      smart00408
      Location:256 → 317
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:48 → 128
      IG; Immunoglobulin
      pfam00629
      Location:748 → 893
      MAM; MAM domain, meprin/A5/mu
      pfam13927
      Location:441 → 518
      Ig_3; Immunoglobulin domain
      cd00096
      Location:461 → 468
      Ig; Ig strand B [structural motif]
      cl11960
      Location:349 → 424
      Ig; Immunoglobulin domain

    RNA

    1. XR_001838168.3 RNA Sequence

    2. XR_001838167.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60756.1 GenPept UniProtKB/Swiss-Prot:P60756

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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