Casz1 castor zinc finger 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Casz1provided by RGD
Official Full Name: castor zinc finger 1provided by RGD
Primary source: RGD:1563533
See related: EnsemblRapid:ENSRNOG00000013474 AllianceGenome:RGD:1563533
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563533
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of neuron differentiation. Predicted to act upstream of or within negative regulation of cell differentiation and retina morphogenesis in camera-type eye. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CASZ1 (castor zinc finger 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 43.7), Heart (RPKM 32.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (164527083..164677037)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (159243965..159393935)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (165625119..165777053)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

BE096150 (e-PCR)
- UniSTS:243994

RH131569 (e-PCR)
- UniSTS:214852

BB450868 (e-PCR)
- UniSTS:207724

RH138182 (e-PCR)
- UniSTS:220269

BI282303 (e-PCR)
- UniSTS:249781

D4Ertd432e (e-PCR), detects polymorphism
- UniSTS:167395

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of amacrine cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of glial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of retinal cone cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of radial glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinal bipolar neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal rod cell fate commitment	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein castor homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427668.2 → NP_001414597.1 zinc finger protein castor homolog 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5ZS43

Related

ENSRNOP00000079561.2, ENSRNOT00000103298.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

164527083..164677037

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008764318.4 → XP_008762540.1 zinc finger protein castor homolog 1 isoform X2

UniProtKB/TrEMBL

A6IU91

Related

ENSRNOP00000081497.2, ENSRNOT00000109654.2

Conserved Domains (1) summary

PHA03247
Location:764 → 1157

PHA03247; large tegument protein UL36; Provisional
XM_017593879.3 → XP_017449368.1 zinc finger protein castor homolog 1 isoform X2

UniProtKB/TrEMBL

A6IU91

Conserved Domains (1) summary

PHA03247
Location:764 → 1157

PHA03247; large tegument protein UL36; Provisional
XM_008764317.4 → XP_008762539.1 zinc finger protein castor homolog 1 isoform X1

UniProtKB/TrEMBL

A6IU91

Conserved Domains (1) summary

PHA03247
Location:788 → 1181

PHA03247; large tegument protein UL36; Provisional
XM_017593880.3 → XP_017449369.1 zinc finger protein castor homolog 1 isoform X3

UniProtKB/TrEMBL

A0A8I6AGF7, A6IU91

Related

ENSRNOP00000091853.1, ENSRNOT00000094206.2