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    Tafa4 TAFA chemokine like family member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689043, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tafa4provided by RGD
    Official Full Name
    TAFA chemokine like family member 4provided by RGD
    Primary source
    RGD:1597443
    See related
    EnsemblRapid:ENSRNOG00000005830 AllianceGenome:RGD:1597443
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam19a4
    Summary
    Predicted to enable receptor ligand activity. Predicted to be involved in several processes, including macrophage chemotaxis; phagocytosis; and superoxide anion generation. Predicted to act upstream of or within regulation of membrane potential and regulation of sensory perception of pain. Predicted to be active in extracellular space; glutamatergic synapse; and synaptic vesicle membrane. Orthologous to human TAFA4 (TAFA chemokine like family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 12.0), Testes (RPKM 7.0) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tafa4 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (130994166..131228032, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (129437466..129671320, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (129196658..129430438, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 1 Neighboring gene uncharacterized LOC120102499 Neighboring gene RNA, U6 small nuclear 131 Neighboring gene uncharacterized LOC134486820 Neighboring gene uncharacterized LOC134486821 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene TATA element modulatory factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TAFA4, a chemokine-like protein, modulates injury-induced mechanical and chemical pain hypersensitivity in mice. Delfini MC, et al. Cell Rep, 2013 Oct 31. PMID 24139797
    2. FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages. Wang W, et al. Cell Mol Immunol, 2015 Sep. PMID 25109685, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    chemokine-like protein TAFA-4
    Names
    family with sequence similarity 19 (chemokine (C-C motif)-like), member A4
    family with sequence similarity 19 member A4, C-C motif chemokine like
    family with sequence similarity 19, member A4
    protein FAM19A4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134700.1 → NP_001128172.1  chemokine-like protein TAFA-4 precursor

      See identical proteins and their annotated locations for NP_001128172.1

      Status: PROVISIONAL

      Source sequence(s)
      BC160856
      UniProtKB/TrEMBL
      B1H244
      Related
      ENSRNOP00000061075.1, ENSRNOT00000067881.3
      Conserved Domains (1) summary
      pfam12020
      Location:45 → 133
      TAFA; TAFA family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      130994166..131228032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286715.1 → XP_063142785.1  chemokine-like protein TAFA-4 isoform X2

      UniProtKB/TrEMBL
      B1H244

    2. XM_063286713.1 → XP_063142783.1  chemokine-like protein TAFA-4 isoform X2

      UniProtKB/TrEMBL
      B1H244

    3. XM_063286714.1 → XP_063142784.1  chemokine-like protein TAFA-4 isoform X2

      UniProtKB/TrEMBL
      B1H244

    4. XM_017592898.3 → XP_017448387.3  chemokine-like protein TAFA-4 isoform X2

      UniProtKB/TrEMBL
      B1H244

    5. XM_039108378.2 → XP_038964306.1  chemokine-like protein TAFA-4 isoform X1

      Conserved Domains (1) summary
      pfam12020
      Location:45 → 132
      TAFA; TAFA family

    6. XM_017592897.3 → XP_017448386.2  chemokine-like protein TAFA-4 isoform X1

      Conserved Domains (1) summary
      pfam12020
      Location:45 → 132
      TAFA; TAFA family
    Nucleotide Protein Strain
    Heading Accession and Version

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