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    Ccdc136 coiled-coil domain containing 136 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362331, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccdc136provided by RGD
    Official Full Name
    coiled-coil domain containing 136provided by RGD
    Primary source
    RGD:1564459
    See related
    EnsemblRapid:ENSRNOG00000007100 AllianceGenome:RGD:1564459
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564459
    Summary
    Predicted to be involved in acrosome assembly and single fertilization. Predicted to be active in acrosomal membrane. Orthologous to human CCDC136 (coiled-coil domain containing 136). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 1128.7) and Brain (RPKM 63.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccdc136 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (58963196..58992962)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (57997825..58027598)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (56674737..56704501)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene opsin 1, short wave sensitive Neighboring gene transfer RNA proline (anticodon AGG) 6 Neighboring gene uncharacterized LOC134486566 Neighboring gene filamin C Neighboring gene ATPase H+ transporting V1 subunit F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A Novel Testis-Specific Gene, Ccdc136, Is Required for Acrosome Formation and Fertilization in Mice. Geng Q, et al. Reprod Sci, 2016 Oct. PMID 27076447
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in acrosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acrosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in acrosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 136

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399577.1 → NP_001386506.1  coiled-coil domain-containing protein 136

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IED0, D4AAR7
      Related
      ENSRNOP00000057058.5, ENSRNOT00000060309.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      58963196..58992962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286243.1 → XP_063142313.1  coiled-coil domain-containing protein 136 isoform X7

    2. XM_039108992.2 → XP_038964920.1  coiled-coil domain-containing protein 136 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AHC3
      Related
      ENSRNOP00000093324.1, ENSRNOT00000110324.2
      Conserved Domains (1) summary
      COG1196
      Location:103 → 406
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_039108991.2 → XP_038964919.1  coiled-coil domain-containing protein 136 isoform X6

      Conserved Domains (2) summary
      COG1196
      Location:103 → 406
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:272 → 588
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    4. XM_008762837.4 → XP_008761059.2  coiled-coil domain-containing protein 136 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZKP3, A6IED1
      Related
      ENSRNOP00000078323.1, ENSRNOT00000112317.2

    5. XM_006236241.5 → XP_006236303.3  coiled-coil domain-containing protein 136 isoform X2

      UniProtKB/TrEMBL
      A6IED0

    6. XM_039108990.2 → XP_038964918.1  coiled-coil domain-containing protein 136 isoform X1

      UniProtKB/TrEMBL
      A6IED0
      Related
      ENSRNOP00000111495.1, ENSRNOT00000146423.1
      Conserved Domains (3) summary
      COG1196
      Location:103 → 406
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:108 → 780
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      NF033930
      Location:801 → 1159
      pneumo_PspA; pneumococcal surface protein A

    7. XM_017592966.3 → XP_017448455.1  coiled-coil domain-containing protein 136 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y6P9, A0A8I6A6S6
      Related
      ENSRNOP00000077755.1, ENSRNOT00000117388.2

    8. XM_063286242.1 → XP_063142312.1  coiled-coil domain-containing protein 136 isoform X5

    9. XM_063286244.1 → XP_063142314.1  coiled-coil domain-containing protein 136 isoform X9

    10. XM_063286245.1 → XP_063142315.1  coiled-coil domain-containing protein 136 isoform X10

    Nucleotide Protein Strain
    Heading Accession and Version

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