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    Gfi1b growth factor independent 1B transcriptional repressor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311832, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gfi1bprovided by RGD
    Official Full Name
    growth factor independent 1B transcriptional repressorprovided by RGD
    Primary source
    RGD:1311727
    See related
    EnsemblRapid:ENSRNOG00000011353 AllianceGenome:RGD:1311727
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of granulocyte differentiation; and regulation of erythrocyte differentiation. Predicted to be located in nuclear matrix; nucleoplasm; and plasma membrane. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in gray platelet syndrome and platelet-type bleeding disorder 17. Orthologous to human GFI1B (growth factor independent 1B transcriptional repressor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 42.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gfi1b in Genome Data Viewer
    Location:
    3p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (32338213..32350963, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (11940232..11952989, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (7190721..7203444, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene general transcription factor IIIC subunit 5 Neighboring gene RNA, U6 small nuclear 592 Neighboring gene TSC complex subunit 1 Neighboring gene sperm acrosome associated 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Growth factor-independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate. Elmaagacli AH, et al. Br J Haematol, 2007 Jan. PMID 17156408
    2. A dominant-negative GFI1B mutation in the gray platelet syndrome. Monteferrario D, et al. N Engl J Med, 2014 Jan 16. PMID 24325358
    3. Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia. Vassen L, et al. Int J Hematol, 2009 May. PMID 19360458
    4. The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation. Tong B, et al. Mol Cell Biol, 1998 May. PMID 9566867, Free PMC Article
    5. Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism. McGhee L, et al. J Cell Biochem, 2003 Aug 1. PMID 12874834

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of hemopoiesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein Gfi-1b
    Names
    growth factor independent 1B transcription repressor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107823.2 → NP_001101293.1  zinc finger protein Gfi-1b

      See identical proteins and their annotated locations for NP_001101293.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      B0BN50, D3ZHB6
      Conserved Domains (4) summary
      PHA00733
      Location:191 → 239
      PHA00733; hypothetical protein
      COG5048
      Location:230 → 307
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:222 → 242
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:262 → 287
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      32338213..32350963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105218.1 → XP_038961146.1  zinc finger protein Gfi-1b isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:217 → 294
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:209 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:249 → 274
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006233789.3 → XP_006233851.1  zinc finger protein Gfi-1b isoform X1

      UniProtKB/TrEMBL
      A0A8J8XL46
      Related
      ENSRNOP00000015236.4, ENSRNOT00000015236.7
      Conserved Domains (3) summary
      COG5048
      Location:263 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:255 → 275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:295 → 320
      zf-H2C2_2; Zinc-finger double domain

    3. XM_039105213.2 → XP_038961141.1  zinc finger protein Gfi-1b isoform X1

      UniProtKB/TrEMBL
      A0A8J8XL46
      Conserved Domains (3) summary
      COG5048
      Location:263 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:255 → 275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:295 → 320
      zf-H2C2_2; Zinc-finger double domain

    4. XM_039105215.2 → XP_038961143.1  zinc finger protein Gfi-1b isoform X1

      UniProtKB/TrEMBL
      A0A8J8XL46
      Conserved Domains (3) summary
      COG5048
      Location:263 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:255 → 275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:295 → 320
      zf-H2C2_2; Zinc-finger double domain

    5. XM_063283925.1 → XP_063139995.1  zinc finger protein Gfi-1b isoform X2

      UniProtKB/TrEMBL
      B0BN50, D3ZHB6

    6. XM_039105214.2 → XP_038961142.1  zinc finger protein Gfi-1b isoform X1

      UniProtKB/TrEMBL
      A0A8J8XL46
      Conserved Domains (3) summary
      COG5048
      Location:263 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:255 → 275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:295 → 320
      zf-H2C2_2; Zinc-finger double domain

    7. XM_039105219.1 → XP_038961147.1  zinc finger protein Gfi-1b isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:217 → 294
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:209 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:249 → 274
      zf-H2C2_2; Zinc-finger double domain

    8. XM_039105216.1 → XP_038961144.1  zinc finger protein Gfi-1b isoform X1

      UniProtKB/TrEMBL
      A0A8J8XL46
      Conserved Domains (3) summary
      COG5048
      Location:263 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:255 → 275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:295 → 320
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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