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    Cdk19 cyclin-dependent kinase 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309804, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdk19provided by RGD
    Official Full Name
    cyclin-dependent kinase 19provided by RGD
    Primary source
    RGD:1305435
    See related
    EnsemblRapid:ENSRNOG00000000583 AllianceGenome:RGD:1305435
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cdk11; Cdc2l6
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in cellular response to lipopolysaccharide and positive regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 87. Orthologous to human CDK19 (cyclin dependent kinase 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 138.4), Spleen (RPKM 101.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdk19 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (45324911..45465121)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (43770409..43910629)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (45458499..45598799)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene adenosylmethionine decarboxylase 1 Neighboring gene vasculin-like protein 1 Neighboring gene transmembrane protein 258, pseudogene 3 Neighboring gene U6 spliceosomal RNA Neighboring gene solute carrier family 22 member 16 Neighboring gene D-aspartate oxidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CDK11(p58) promotes rat astrocyte inflammatory response via activating p38 and JNK pathways induced by lipopolysaccharide. Liu X, et al. Neurochem Res, 2012 Mar. PMID 22120654
    2. LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11(p58) expression in PC12 cells through downregulating AKT pathway. Liu X, et al. Cell Mol Neurobiol, 2013 Aug. PMID 23703121
    3. Cyclin D3/CDK11(p58) complex involved in Schwann cells proliferation repression caused by lipopolysaccharide. Duan Y, et al. Inflammation, 2010 Jun. PMID 20066559
    4. Increased expression of CDK11p58 and cyclin D3 following spinal cord injury in rats. Ji Y, et al. Mol Cell Biochem, 2008 Feb. PMID 18008145
    5. The functional interaction between CDK11p58 and β-1,4-galactosyltransferase I involved in astrocyte activation caused by lipopolysaccharide. Liu X, et al. Inflammation, 2012 Aug. PMID 22527143

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 19
    Names
    cell division cycle 2-like 6 (CDK8-like)
    cell division protein kinase 19
    cyclin-dependent kinase (CDC2-like) 11
    NP_001101104.1
    XP_008771207.1
    XP_008771208.1
    XP_017457146.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107634.1 → NP_001101104.1  cyclin-dependent kinase 19

      See identical proteins and their annotated locations for NP_001101104.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474051
      UniProtKB/TrEMBL
      A0A8I5ZUQ1, A6KIJ0, A6KIJ1, D3ZDM6
      Related
      ENSRNOP00000000713.5, ENSRNOT00000000713.7
      Conserved Domains (2) summary
      smart00220
      Location:22 → 335
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07867
      Location:18 → 335
      STKc_CDC2L6; Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      45324911..45465121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772985.4 → XP_008771207.1  cyclin-dependent kinase 19 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1 → 215
      PKc_like; Protein Kinases, catalytic domain

    2. XM_017601657.3 → XP_017457146.1  cyclin-dependent kinase 19 isoform X1

    3. XM_008772986.4 → XP_008771208.1  cyclin-dependent kinase 19 isoform X3

      See identical proteins and their annotated locations for XP_008771208.1

      UniProtKB/TrEMBL
      A6KIJ3
      Conserved Domains (1) summary
      cl21453
      Location:1 → 162
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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