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    Gbp1 guanylate binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304266, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Gbp1provided by RGD
    Official Full Name
    guanylate binding protein 1provided by RGD
    Primary source
    RGD:1311877
    See related
    EnsemblRapid:ENSRNOG00000068984 AllianceGenome:RGD:1311877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including cytoskeletal protein binding activity; guanyl ribonucleotide binding activity; and pyrophosphatase activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; regulation of signal transduction; and response to bacterium. Predicted to act upstream of or within adhesion of symbiont to host; cellular response to interferon-beta; and defense response to other organism. Predicted to be located in Golgi apparatus; actin cytoskeleton; and cytosol. Predicted to be active in cytoplasmic vesicle; symbiont cell surface; and vesicle membrane. Orthologous to several human genes including GBP1 (guanylate binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 418.1) and Muscle (RPKM 28.7) See more
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    Genomic context

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    See Gbp1 in Genome Data Viewer
    Location:
    2q44
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (234071366..234106012)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (231398136..231432773)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (248343334..248423402)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene guanylate binding protein 2 Neighboring gene uncharacterized LOC134485987 Neighboring gene guanylate-binding protein 3-like Neighboring gene guanylate binding protein 3 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tetramerization of human guanylate-binding protein 1 is mediated by coiled-coil formation of the C-terminal α-helices. Syguda A, et al. FEBS J, 2012 Jul. PMID 22607347
    2. The guanine cap of human guanylate-binding protein 1 is responsible for dimerization and self-activation of GTP hydrolysis. Wehner M, et al. FEBS J, 2012 Jan. PMID 22059445
    3. How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP. Ghosh A, et al. Nature, 2006 Mar 2. PMID 16511497
    4. Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins. Prakash B, et al. Nature, 2000 Feb 3. PMID 10676968
    5. Interferon-induced guanylate-binding proteins: mapping of the murine Gbp-1 locus to chromosome 3. Prochazka M, et al. Virology, 1985 Sep. PMID 3927587

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GMP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytokine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adhesion of symbiont to host ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to type II interferon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytolysis in another organism ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within defense response to protozoan ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to protozoan ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-canonical inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of pyroptotic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to vacuole ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in symbiont cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interferon-induced guanylate-binding protein 1; guanylate-binding protein 1
    Names
    guanylate binding protein 1, interferon-inducible, 67kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433102.1 → NP_001420031.1  interferon-induced guanylate-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6GE08

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      234071366..234106012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591353.3 → XP_017446842.2  guanylate-binding protein 1

      Related
      ENSRNOP00000086405.1, ENSRNOT00000094466.2
      Conserved Domains (3) summary
      PTZ00121
      Location:439 → 773
      PTZ00121; MAEBL; Provisional
      pfam02263
      Location:20 → 283
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:285 → 581
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. XM_039103866.2 → XP_038959794.1  guanylate-binding protein 1

      UniProtKB/TrEMBL
      A0A8I6GE08
      Conserved Domains (3) summary
      PTZ00121
      Location:439 → 773
      PTZ00121; MAEBL; Provisional
      pfam02263
      Location:20 → 283
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:285 → 581
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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