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    Scamp3 secretory carrier membrane protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65169, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Scamp3provided by RGD
    Official Full Name
    secretory carrier membrane protein 3provided by RGD
    Primary source
    RGD:68351
    See related
    EnsemblRapid:ENSRNOG00000020500 AllianceGenome:RGD:68351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein phosphorylation and protein transport. Predicted to act upstream of or within response to retinoic acid. Predicted to be located in Golgi membrane. Orthologous to several human genes including CLK2 (CDC like kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 183.1), Thymus (RPKM 146.4) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Scamp3 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176880873..176886750)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174583124..174588984)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188488907..188495147)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene pyruvate kinase L/R Neighboring gene hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 Neighboring gene CDC-like kinase 2 Neighboring gene microRNA 3541 Neighboring gene endosomal transmembrane epsin interactor 3 Neighboring gene uncharacterized LOC102550011 Neighboring gene glucosylceramidase beta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nonredundant function of secretory carrier membrane protein isoforms in dense core vesicle exocytosis. Liao H, et al. Am J Physiol Cell Physiol, 2008 Mar. PMID 18171723
    2. Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions. Fernández-Chacón R, et al. J Neurosci, 2000 Nov 1. PMID 11050114, Free PMC Article
    3. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. Smith CJ, et al. J Cell Sci, 2013 Mar 15. PMID 23418353
    4. Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. Kunarso G, et al. BMC Genomics, 2008 Apr 9. PMID 18400104, Free PMC Article
    5. Proteomics characterization of abundant Golgi membrane proteins. Bell AW, et al. J Biol Chem, 2001 Feb 16. PMID 11042173

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCAMP isoforms regulate membrane fusion and dense core vesicle exocytosis in neurons.
      Title: Nonredundant function of secretory carrier membrane protein isoforms in dense core vesicle exocytosis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    secretory carrier-associated membrane protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031724.1 → NP_113912.1  secretory carrier-associated membrane protein 3

      Status: VALIDATED

      Source sequence(s)
      BQ783359, CK599635, DV726194
      UniProtKB/TrEMBL
      A0A8I6GC12, E9PTW1
      Related
      ENSRNOP00000027815.6, ENSRNOT00000027815.8
      Conserved Domains (1) summary
      pfam04144
      Location:135 → 310
      SCAMP; SCAMP family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176880873..176886750
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232753.5 → XP_006232815.1  secretory carrier-associated membrane protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006232815.1

      UniProtKB/TrEMBL
      A0A8I6GC12, A6J6C4
      Related
      ENSRNOP00000084600.1, ENSRNOT00000111900.2
      Conserved Domains (1) summary
      pfam04144
      Location:134 → 309
      SCAMP; SCAMP family

    2. XM_006232754.5 → XP_006232816.1  secretory carrier-associated membrane protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GC12
      Conserved Domains (1) summary
      pfam04144
      Location:94 → 269
      SCAMP; SCAMP family
    Nucleotide Protein Strain
    Heading Accession and Version

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