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    Nob1 NIN1 (RPN12) binding protein 1 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291996, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nob1provided by RGD
    Official Full Name
    NIN1 (RPN12) binding protein 1 homologprovided by RGD
    Primary source
    RGD:735222
    See related
    EnsemblRapid:ENSRNOG00000021890 AllianceGenome:RGD:735222
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nob1p
    Summary
    Predicted to enable RNA endonuclease activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to act upstream of or within visual perception. Predicted to be located in nucleus. Predicted to be part of preribosome, small subunit precursor. Orthologous to human NOB1 (NIN1 (RPN12) binding protein 1 homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 95.7), Kidney (RPKM 80.9) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nob1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (52232543..52245824, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (35322803..35335354, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (38397466..38409924)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T-cells 5 Neighboring gene uncharacterized LOC134483351 Neighboring gene NAD(P)H quinone dehydrogenase 1 Neighboring gene WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene eukaryotic translation initiation factor 5B, pseudogene 1 Neighboring gene microRNA 140

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC156557

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ribosomal small subunit biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within visual perception ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of preribosome, small subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    RNA-binding protein NOB1
    Names
    NIN1/PSMD8 binding protein 1 homolog
    nin one binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199086.1NP_954517.1  RNA-binding protein NOB1

      See identical proteins and their annotated locations for NP_954517.1

      Status: PROVISIONAL

      Source sequence(s)
      AY341886
      UniProtKB/Swiss-Prot
      A0JN09, Q6VEU1
      UniProtKB/TrEMBL
      A0A8L2UKR4, A6IZ01
      Related
      ENSRNOP00000031905.4, ENSRNOT00000034386.6
      Conserved Domains (4) summary
      cd09876
      Location:7115
      PIN_Nob1; PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein Ta0041-like homologs
      COG1439
      Location:8299
      Nob1; rRNA maturation endonuclease Nob1 [Translation, ribosomal structure and biogenesis]
      pfam15017
      Location:135218
      AF1Q; Drug resistance and apoptosis regulator
      pfam08772
      Location:258330
      NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      52232543..52245824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277929.1XP_063133999.1  RNA-binding protein NOB1 isoform X2

    2. XM_063277928.1XP_063133998.1  RNA-binding protein NOB1 isoform X1