Pggt1b protein geranylgeranyltransferase type I subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pggt1bprovided by RGD
Official Full Name: protein geranylgeranyltransferase type I subunit betaprovided by RGD
Primary source: RGD:621754
See related: EnsemblRapid:ENSRNOG00000003541 AllianceGenome:RGD:621754
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables heterocyclic compound binding activity. Contributes to CAAX-protein geranylgeranyltransferase activity; peptide binding activity; and zinc ion binding activity. Involved in several processes, including negative regulation of nitric-oxide synthase biosynthetic process; positive regulation of cell population proliferation; and protein geranylgeranylation. Part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human PGGT1B (protein geranylgeranyltransferase type I subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 112.3), Spleen (RPKM 110.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (41138536..41182145, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (38952147..38995656, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (40173236..40218225, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that geranylgeranyltransferase I (GGT) plays an important role in Purkinje cell development, and suggest a novel role of GGT in neuronal morphogenesis in vivo.
Title: Geranylgeranyltransferase I is essential for dendritic development of cerebellar Purkinje cells.
lysine beta311 of GGTase I partially replaces the catalytic function of Mg(II) observed in FTas
Title: Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to CAAX-protein geranylgeranyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to CAAX-protein geranylgeranyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables CAAX-protein geranylgeranyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables CAAX-protein geranylgeranyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables heterocyclic compound binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein geranylgeranyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein geranylgeranyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein geranylgeranyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein prenyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to small molecule binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein geranylgeranylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein geranylgeranylation	ISO Inferred from Sequence Orthology more info
involved_in protein geranylgeranylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein geranylgeranylation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of CAAX-protein geranylgeranyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CAAX-protein geranylgeranyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of CAAX-protein geranylgeranyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of CAAX-protein geranylgeranyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of CAAX-protein geranylgeranyltransferase complex	TAS Traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: geranylgeranyl transferase type-1 subunit beta

Names: GGTase-I-beta; geranylgeranyl transferase type I subunit beta; geranylgeranyltransferase type 1 beta; geranylgeranyltransferase type I (GGTase-I); protein geranylgeranyltransferase type 1 subunit beta; protein geranylgeranyltransferase type I, beta subunit; type I protein geranyl-geranyltransferase subunit beta

NP_112344.1

EC 2.5.1.59

XP_008770399.1

EC 2.5.1.59

XP_038953068.1

EC 2.5.1.59

XP_038953069.1

EC 2.5.1.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031082.2 → NP_112344.1 geranylgeranyl transferase type-1 subunit beta

See identical proteins and their annotated locations for NP_112344.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

P53610

UniProtKB/TrEMBL

A0A8I6A578, A6IWV1

Related

ENSRNOP00000004723.1, ENSRNOT00000004723.5

Conserved Domains (1) summary

cd02895
Location:22 → 332

GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

41138536..41182145 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772177.4 → XP_008770399.1 geranylgeranyl transferase type-1 subunit beta isoform X1

See identical proteins and their annotated locations for XP_008770399.1

UniProtKB/TrEMBL

A0A8I6A578

Related

ENSRNOP00000095779.2, ENSRNOT00000103699.2

Conserved Domains (1) summary

cd02895
Location:2 → 273

GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...
XM_039097140.2 → XP_038953068.1 geranylgeranyl transferase type-1 subunit beta isoform X2

Conserved Domains (1) summary

cd02895
Location:1 → 209

GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...
XM_039097141.2 → XP_038953069.1 geranylgeranyl transferase type-1 subunit beta isoform X3

Conserved Domains (1) summary

cl08267
Location:22 → 220

ISOPREN_C2_like; This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...