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    Ccdc68 coiled-coil domain containing 68 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291530, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ccdc68provided by RGD
    Official Full Name
    coiled-coil domain containing 68provided by RGD
    Primary source
    RGD:1561424
    See related
    EnsemblRapid:ENSRNOG00000021381 AllianceGenome:RGD:1561424
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561424
    Summary
    Predicted to be involved in microtubule anchoring at centrosome and protein localization. Predicted to be part of centriolar subdistal appendage. Predicted to be active in centriole. Orthologous to human CCDC68 (coiled-coil domain containing 68). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 53.9), Uterus (RPKM 19.3) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccdc68 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (65817232..65859529)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (63541828..63584122)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (68408812..68472323)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene transcription factor 4 Neighboring gene uncharacterized LOC134482985 Neighboring gene RAB27B, member RAS oncogene family Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68. Huang N, et al. Nat Commun, 2017 Apr 19. PMID 28422092, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in microtubule anchoring at centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule anchoring at centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of centriolar subdistal appendage ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 68
    Names
    CTCL tumor antigen se57-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077667.1 → NP_001071135.1  coiled-coil domain-containing protein 68

      See identical proteins and their annotated locations for NP_001071135.1

      Status: PROVISIONAL

      Source sequence(s)
      BC127517
      UniProtKB/TrEMBL
      A0A8I5ZSZ9, A0JPN5, A6IXZ2
      Related
      ENSRNOP00000029680.4, ENSRNOT00000039702.6
      Conserved Domains (1) summary
      pfam16046
      Location:150 → 235
      FAM76; FAM76 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      65817232..65859529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277189.1 → XP_063133259.1  coiled-coil domain-containing protein 68 isoform X2

    2. XM_039096658.2 → XP_038952586.1  coiled-coil domain-containing protein 68 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y0E9, A6IXZ1
      Related
      ENSRNOP00000076540.1, ENSRNOT00000110274.2
      Conserved Domains (1) summary
      COG1196
      Location:84 → 298
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_039096659.2 → XP_038952587.1  coiled-coil domain-containing protein 68 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y0E9, A6IXZ1
      Related
      ENSRNOP00000103687.1, ENSRNOT00000163618.1
      Conserved Domains (1) summary
      COG1196
      Location:84 → 298
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_005496000.2 RNA Sequence

    2. XR_005495999.2 RNA Sequence

    3. XR_005496002.2 RNA Sequence

    4. XR_005496001.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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