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    Pter phosphotriesterase related [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63852, updated on 21-Dec-2024

    Summary

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    Official Symbol
    Pterprovided by RGD
    Official Full Name
    phosphotriesterase relatedprovided by RGD
    Primary source
    RGD:61313
    See related
    EnsemblRapid:ENSRNOG00000017328 AllianceGenome:RGD:61313
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rpr1; Rpr-1
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds and zinc ion binding activity. Predicted to be involved in epithelial cell differentiation. Orthologous to human PTER (phosphotriesterase related). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 462.1) and Spleen (RPKM 29.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pter in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (80967463..81028707)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (76058388..76119633)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (80250444..80311987)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555562 Neighboring gene uncharacterized LOC108348618 Neighboring gene uncharacterized LOC134482609 Neighboring gene complement C1q like 3 Neighboring gene Ras suppressor protein 1 Neighboring gene uncharacterized LOC134482610

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression pattern of rpr-1, a resiniferatoxin-binding, phosphotriesterase-related protein, expressed in rat kidney tubules. Davies JA, et al. FEBS Lett, 1997 Jun 30. PMID 9237666
    2. Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Buhrke T, et al. Dev Growth Differ, 2011 Apr. PMID 21492153
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyltaurine hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetyltaurine hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of appetite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in taurine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in taurine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyltaurine hydrolase; phosphotriesterase-related protein
    Names
    parathion hydrolase-related protein
    resiniferatoxin-binding, phosphotriesterase-related protein
    resiniferotoxin-binding phosphotriesterase-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022224.2 → NP_071560.2  N-acetyltaurine hydrolase

      See identical proteins and their annotated locations for NP_071560.2

      Status: PROVISIONAL

      Source sequence(s)
      BC078833
      UniProtKB/Swiss-Prot
      Q63530, Q6AYY7
      UniProtKB/TrEMBL
      A0A8I5ZP46, A6JM34
      Related
      ENSRNOP00000104743.1, ENSRNOT00000148097.1
      Conserved Domains (1) summary
      cl00281
      Location:15 → 347
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      80967463..81028707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254291.5 → XP_006254353.1  phosphotriesterase-related protein isoform X3

      See identical proteins and their annotated locations for XP_006254353.1

      UniProtKB/Swiss-Prot
      Q63530, Q6AYY7
      UniProtKB/TrEMBL
      A0A8I5ZP46, A6JM34
      Related
      ENSRNOP00000023446.2, ENSRNOT00000023446.6
      Conserved Domains (1) summary
      cl00281
      Location:15 → 347
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    2. XM_039096043.2 → XP_038951971.1  phosphotriesterase-related protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZP46
      Conserved Domains (1) summary
      cl00281
      Location:59 → 391
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    3. XM_006254290.5 → XP_006254352.3  phosphotriesterase-related protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZP46
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63530.2 GenPept UniProtKB/Swiss-Prot:Q63530

    Gene LinkOut

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