Tspan17 tetraspanin 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tspan17provided by RGD
Official Full Name: tetraspanin 17provided by RGD
Primary source: RGD:1311167
See related: EnsemblRapid:ENSRNOG00000018122 AllianceGenome:RGD:1311167
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GHB-R; Fbxo23
Summary: Predicted to enable enzyme binding activity. Predicted to be involved in establishment of protein localization to organelle; protein maturation; and regulation of membrane protein ectodomain proteolysis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TSPAN17 (tetraspanin 17). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 115.3), Testes (RPKM 78.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (9824353..9831985, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (9819212..9826851, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (10356980..10364614, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that ethanol does not affect [(3)H]NCS-382 binding in the rat brain, thereby suggesting that ethanol does not interact directly with the GHB receptor.
Title: Characterization and pharmacology of the GHB receptor.
Immunohistochemical analyses showed receptor protein distribution closely resembling the distribution of GHB high-affinity binding sites, except for cerebellum. The GHB receptor-like protein labeling appears to be distributed specifically in neurons.
Title: Immunohistochemical localization of a GHB receptor-like protein isolated from rat brain.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in establishment of protein localization to organelle	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to organelle	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tetraspanin-17

Names: F-box only protein 23; gamma-hydroxybutyrate receptor; tspan-17

NP_001013156.2

EC 3.6.5.3

XP_006253692.1

EC 3.6.5.3

XP_006253693.1

EC 3.6.5.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013138.2 → NP_001013156.2 tetraspanin-17

See identical proteins and their annotated locations for NP_001013156.2

Status: VALIDATED

Source sequence(s)

BC097431, FM038661

UniProtKB/Swiss-Prot

Q4V8E0

UniProtKB/TrEMBL

A0A8L2QNH2, A6KAW7

Related

ENSRNOP00000049736.4, ENSRNOT00000041709.6

Conserved Domains (1) summary

cd03159
Location:115 → 235

TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

9824353..9831985 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253631.5 → XP_006253693.1 tetraspanin-17 isoform X2

UniProtKB/TrEMBL

A0A8L2QNH2

Conserved Domains (1) summary

cd03159
Location:66 → 186

TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
XM_006253630.5 → XP_006253692.1 tetraspanin-17 isoform X1

See identical proteins and their annotated locations for XP_006253692.1

UniProtKB/TrEMBL

A0A0G2JZH6, A0A8L2QNH2, A6KAW6

Related

ENSRNOP00000071050.1, ENSRNOT00000086380.3

Conserved Domains (1) summary

cd03159
Location:115 → 235

TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...