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    Hormad2 HORMA domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498400, updated on 9-Dec-2024

    Summary

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    Symbol
    Hormad2provided by RGD
    Full Name
    HORMA domain containing 2provided by RGD
    Primary source
    RGD:1565447
    See related
    EnsemblRapid:ENSRNOG00000037865 AllianceGenome:RGD:1565447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in meiotic cell cycle and meiotic sister chromatid cohesion. Predicted to be located in centrosome; cytosol; and nuclear lumen. Orthologous to human HORMAD2 (HORMA domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 42.8), Adrenal (RPKM 32.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hormad2 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (83438555..83524015, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (79215013..79300447, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (84576856..84662237, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene LIF, interleukin 6 family cytokine Neighboring gene U4 spliceosomal RNA Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene U2 spliceosomal RNA Neighboring gene myotubularin related protein 3 Neighboring gene activating signal cointegrator 1 complex subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. Wojtasz L, et al. PLoS Genet, 2009 Oct. PMID 19851446, Free PMC Article
    2. Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms. Wojtasz L, et al. Genes Dev, 2012 May 1. PMID 22549958, Free PMC Article
    3. HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Kogo H, et al. Genes Cells, 2012 Nov. PMID 23039116
    4. Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. Jordan PW, et al. J Cell Sci, 2012 Nov 1. PMID 22854038, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in meiotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptonemal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    HORMA domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017501.1 → NP_001017501.1  HORMA domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001017501.1

      Status: VALIDATED

      Source sequence(s)
      BC079253
      UniProtKB/TrEMBL
      Q6AXZ7
      Conserved Domains (1) summary
      pfam02301
      Location:31 → 186
      HORMA; HORMA domain

    2. NM_001401619.1 → NP_001388548.1  HORMA domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2JU34
      Related
      ENSRNOP00000068948.1, ENSRNOT00000080078.3
      Conserved Domains (1) summary
      pfam02301
      Location:31 → 226
      HORMA; HORMA domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      83438555..83524015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273477.1 → XP_063129547.1  HORMA domain-containing protein 2 isoform X4

    2. XM_063273476.1 → XP_063129546.1  HORMA domain-containing protein 2 isoform X3

    3. XM_039092294.2 → XP_038948222.1  HORMA domain-containing protein 2 isoform X2

      Related
      ENSRNOP00000054338.3, ENSRNOT00000057529.4
      Conserved Domains (1) summary
      pfam02301
      Location:31 → 217
      HORMA; HORMA domain

    4. XM_008770343.4 → XP_008768565.2  HORMA domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU34
      Conserved Domains (1) summary
      pfam02301
      Location:31 → 226
      HORMA; HORMA domain

    5. XM_008770342.4 → XP_008768564.2  HORMA domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU34
      Conserved Domains (1) summary
      pfam02301
      Location:31 → 226
      HORMA; HORMA domain

    6. XM_008770341.4 → XP_008768563.2  HORMA domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU34
      Conserved Domains (1) summary
      pfam02301
      Location:31 → 226
      HORMA; HORMA domain
    Nucleotide Protein Strain
    Heading Accession and Version

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