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    Thoc5 THO complex subunit 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360972, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Thoc5provided by RGD
    Official Full Name
    THO complex subunit 5provided by RGD
    Primary source
    RGD:1304991
    See related
    EnsemblRapid:ENSRNOG00000008456 AllianceGenome:RGD:1304991
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fmip
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus; monocyte differentiation; and primitive hemopoiesis. Predicted to act upstream of or within several processes, including negative regulation of macrophage differentiation; regulation of mRNA export from nucleus; and regulation of stem cell division. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of THO complex part of transcription export complex. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human THOC5 (THO complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 105.2), Brain (RPKM 93.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Thoc5 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (83982302..84016193)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (79758805..79792718)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (85138219..85171729)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Neighboring gene nipsnap homolog 1 Neighboring gene U7 small nuclear RNA Neighboring gene U7 small nuclear RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. THOC5 couples M-CSF receptor signaling to transcription factor expression. Carney L, et al. Cell Signal, 2009 Feb. PMID 19015024
    2. THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. Mancini A, et al. BMC Biol, 2010 Jan 5. PMID 20051105, Free PMC Article
    3. Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). El Bounkari O, et al. FEBS Lett, 2009 Jan 5. PMID 19059247
    4. The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation. Mancini A, et al. Oncogene, 2004 Aug 26. PMID 15221008
    5. FMIP, a novel Fms-interacting protein, affects granulocyte/macrophage differentiation. Tamura T, et al. Oncogene, 1999 Nov 11. PMID 10597251

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within blastocyst development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in primitive hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in primitive hemopoiesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of stem cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within stem cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of THO complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of THO complex part of transcription export complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of THO complex part of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    THO complex subunit 5 homolog
    Names
    Fms interacting protein
    THO complex 5
    fms-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012153.2 → NP_001012153.1  THO complex subunit 5 homolog isoform 1

      See identical proteins and their annotated locations for NP_001012153.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q68FX7
      UniProtKB/TrEMBL
      A0A8I6AF30
      Related
      ENSRNOP00000011281.8, ENSRNOT00000011281.8
      Conserved Domains (1) summary
      pfam09766
      Location:103 → 451
      FimP; Fms-interacting protein

    2. NM_001401407.1 → NP_001388336.1  THO complex subunit 5 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZVV2, A0A8I6AF30, A6IKJ0
      Related
      ENSRNOP00000103476.1, ENSRNOT00000160359.1

    3. NM_001401408.1 → NP_001388337.1  THO complex subunit 5 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AF30, A0A8L2Q5G3, A6IKJ1
      Related
      ENSRNOP00000077470.1, ENSRNOT00000115858.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      83982302..84016193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092214.2 → XP_038948142.1  THO complex subunit 5 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6AHC9
      Conserved Domains (1) summary
      pfam09766
      Location:81 → 425
      FimP; Fms-interacting protein

    2. XM_039092215.2 → XP_038948143.1  THO complex subunit 5 homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I6AHC9
      Related
      ENSRNOP00000087796.1, ENSRNOT00000110992.2
      Conserved Domains (1) summary
      pfam09766
      Location:81 → 414
      FimP; Fms-interacting protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FX7.1 GenPept UniProtKB/Swiss-Prot:Q68FX7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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