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    Mtf2 metal response element binding transcription factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtf2provided by RGD
    Official Full Name
    metal response element binding transcription factor 2provided by RGD
    Primary source
    RGD:1304727
    See related
    EnsemblRapid:ENSRNOG00000000075 AllianceGenome:RGD:1304727
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304727
    Summary
    Predicted to enable several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; methylated histone binding activity; and transcription corepressor binding activity. Predicted to be involved in several processes, including negative regulation of gene expression, epigenetic; segment specification; and stem cell population maintenance. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Orthologous to human MTF2 (metal response element binding transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 242.5), Spleen (RPKM 94.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtf2 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (1784218..1828463, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (1639256..1683513, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (2656776..2701027, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein 5 Neighboring gene adaptor related protein complex 2 subunit sigma 1, pseudogene 1 Neighboring gene histone cluster 2 H2B family member E, pseudogene 1 Neighboring gene 60S ribosomal protein L34 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: the one hybrid system. Inouye C, et al. DNA Cell Biol, 1994 Jul. PMID 7772254
    2. Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Musselman CA, et al. Nat Struct Mol Biol, 2012 Dec. PMID 23142980, Free PMC Article
    3. Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney. Mididoddi S, et al. Toxicol Lett, 1996 Apr. PMID 8619255
    4. Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes. Li X, et al. Mol Cell Biol, 2011 Jan. PMID 21059868, Free PMC Article
    5. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Herz HM, et al. Trends Biochem Sci, 2013 Dec. PMID 24148750, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epigenetic regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in segment specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metal-response element-binding transcription factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100898.1 → NP_001094368.1  metal-response element-binding transcription factor 2

      Status: PROVISIONAL

      Source sequence(s)
      BC093403, BC160928, EV774388
      UniProtKB/TrEMBL
      A0A8I6G9Y9, F1LMD5
      Related
      ENSRNOP00000082819.1, ENSRNOT00000114569.2
      Conserved Domains (4) summary
      smart00333
      Location:45 → 95
      TUDOR; Tudor domain
      cd15578
      Location:104 → 156
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:203 → 254
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:544 → 590
      Mtf2_C; Polycomb-like MTF2 factor 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      1784218..1828463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250569.5 → XP_006250631.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      B1H2A5
      Conserved Domains (3) summary
      cd15578
      Location:2 → 54
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101 → 152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442 → 488
      Mtf2_C; Polycomb-like MTF2 factor 2

    2. XM_039092150.2 → XP_038948078.1  metal-response element-binding transcription factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSG2, A0A8I6G9Y9
      Related
      ENSRNOP00000081260.1, ENSRNOT00000098983.2
      Conserved Domains (4) summary
      cd15578
      Location:115 → 167
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:214 → 265
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:555 → 602
      Mtf2_C; Polycomb-like MTF2 factor 2
      cd20450
      Location:56 → 109
      Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins

    3. XM_063273317.1 → XP_063129387.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      B1H2A5

    4. XM_063273316.1 → XP_063129386.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      B1H2A5

    5. XM_063273319.1 → XP_063129389.1  metal-response element-binding transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      B1H2A5

    RNA

    1. XR_005492985.2 RNA Sequence

    2. XR_005492986.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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