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    Ewsr1 EWS RNA-binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289752, updated on 9-Dec-2024

    Summary

    Symbol
    Ewsr1provided by RGD
    Full Name
    EWS RNA-binding protein 1provided by RGD
    Primary source
    RGD:1307258
    See related
    EnsemblRapid:ENSRNOG00000009437 AllianceGenome:RGD:1307258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity; identical protein binding activity; and transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Located in Cajal body. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 597.9), Spleen (RPKM 406.4) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ewsr1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84179413..84208149, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (79965365..79994108, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (85322105..85350826, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096647 Neighboring gene RAS-like, family 10, member A Neighboring gene growth arrest-specific 2 like 1 Neighboring gene rhomboid domain containing 3 Neighboring gene EMI domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC112874

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RNA-binding protein EWS
    Names
    Ewing sarcoma breakpoint region 1
    RNA-binding protein EWS-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025632.3NP_001020803.2  RNA-binding protein EWS isoform 2

      See identical proteins and their annotated locations for NP_001020803.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2K850, A0A9K3Y8I9, B1WC50, F1LN98, F1MA60
      Related
      ENSRNOP00000074472.2, ENSRNOT00000086607.3
      Conserved Domains (3) summary
      sd00025
      Location:521542
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:517546
      zf-RanBP; Zn-finger in Ran binding protein and others
      cd12533
      Location:360443
      RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)
    2. NM_001434406.1NP_001421335.1  RNA-binding protein EWS isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2K850

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      84179413..84208149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251203.5XP_006251265.2  RNA-binding protein EWS isoform X3

      Related
      ENSRNOP00000012634.7, ENSRNOT00000012634.8
      Conserved Domains (3) summary
      sd00025
      Location:522543
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:518547
      zf-RanBP; Zn-finger in Ran binding protein and others
      cd12533
      Location:361444
      RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)
    2. XM_006251202.5XP_006251264.2  RNA-binding protein EWS isoform X2

      See identical proteins and their annotated locations for XP_006251264.2

      UniProtKB/TrEMBL
      A0A0G2JWK8, A0A140UHY3, A0A8J8Y9N6
      Related
      ENSRNOP00000069920.3, ENSRNOT00000083464.3
      Conserved Domains (4) summary
      PRK12438
      Location:53147
      PRK12438; hypothetical protein; Provisional
      sd00025
      Location:527548
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:523552
      zf-RanBP; Zn-finger in Ran binding protein and others
      cd12533
      Location:366449
      RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)
    3. XM_006251201.5XP_006251263.2  RNA-binding protein EWS isoform X1

      See identical proteins and their annotated locations for XP_006251263.2

      UniProtKB/TrEMBL
      A0A8J8Y9N6
      Related
      ENSRNOP00000054193.5, ENSRNOT00000057382.6
      Conserved Domains (4) summary
      PRK12438
      Location:53147
      PRK12438; hypothetical protein; Provisional
      sd00025
      Location:528549
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:524553
      zf-RanBP; Zn-finger in Ran binding protein and others
      cd12533
      Location:367450
      RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)
    4. XM_063272946.1XP_063129016.1  RNA-binding protein EWS isoform X4

    5. XM_039091737.2XP_038947665.1  RNA-binding protein EWS isoform X6

      UniProtKB/TrEMBL
      Q4KM41
      Conserved Domains (3) summary
      sd00025
      Location:183204
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:179208
      zf-RanBP; Zn-finger in Ran binding protein and others
      cd12533
      Location:22105
      RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)
    6. XM_063272947.1XP_063129017.1  RNA-binding protein EWS isoform X5

    7. XM_008770260.4XP_008768482.3  RNA-binding protein EWS isoform X7

      UniProtKB/TrEMBL
      A0A8I6A3F5
      Related
      ENSRNOP00000085477.1, ENSRNOT00000094261.2