Mtarc1 mitochondrial amidoxime reducing component 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mtarc1provided by RGD
Official Full Name: mitochondrial amidoxime reducing component 1provided by RGD
Primary source: RGD:1592219
See related: EnsemblRapid:ENSRNOG00000037850 AllianceGenome:RGD:1592219
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Marc1; Mosc1
Summary: Predicted to enable molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on other nitrogenous compounds as donors. Predicted to contribute to nitrite reductase (NO-forming) activity. Predicted to be involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Predicted to be located in mitochondrion. Predicted to be part of nitric-oxide synthase complex. Orthologous to human MTARC1 (mitochondrial amidoxime reducing component 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 730.7), Kidney (RPKM 188.6) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13q26

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (98854235..98894208, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (96324377..96362677, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (102693679..102724120, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW534190 (e-PCR)
- UniSTS:246555

BI277273 (e-PCR)
- UniSTS:243674

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molybdenum ion binding	ISO Inferred from Sequence Orthology more info
enables molybdopterin cofactor binding	ISO Inferred from Sequence Orthology more info
enables nitrate reductase activity	ISO Inferred from Sequence Orthology more info
contributes_to nitrite reductase (NO-forming) activity	ISO Inferred from Sequence Orthology more info
enables nitrite reductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on other nitrogenous compounds as donors	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular detoxification of nitrogen compound	ISO Inferred from Sequence Orthology more info
involved_in nitrate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of nitric-oxide synthase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial amidoxime-reducing component 1

Names: MOCO sulphurase C-terminal domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100811.1 → NP_001094281.1 mitochondrial amidoxime-reducing component 1

See identical proteins and their annotated locations for NP_001094281.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6JGP5, D3Z900, G3V6I4

Related

ENSRNOP00000034963.6, ENSRNOT00000029439.8

Conserved Domains (3) summary

COG3217
Location:60 → 339

YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]

pfam03473
Location:207 → 336

MOSC; MOSC domain

pfam03476
Location:58 → 179

MOSC_N; MOSC N-terminal beta barrel domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

98854235..98894208 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091110.2 → XP_038947038.1 mitochondrial amidoxime-reducing component 1 isoform X2

UniProtKB/TrEMBL

A6JGP6

Conserved Domains (1) summary

COG3217
Location:60 → 299

YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
XM_063272629.1 → XP_063128699.1 mitochondrial amidoxime-reducing component 1 isoform X1