Kcnk2 potassium two pore domain channel subfamily K member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnk2provided by RGD
Official Full Name: potassium two pore domain channel subfamily K member 2provided by RGD
Primary source: RGD:621448
See related: EnsemblRapid:ENSRNOG00000002653 AllianceGenome:RGD:621448
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trek-1; rTREK1d
Summary: Enables channel activity and potassium channel inhibitor activity. Involved in several processes, including cellular response to arachidonate; detection of mechanical stimulus involved in sensory perception of touch; and negative regulation of cardiac muscle cell proliferation. Located in several cellular components, including apical plasma membrane; astrocyte projection; and axon. Used to study transient cerebral ischemia. Biomarker of brain ischemia; congestive heart failure; myocardial infarction; and transient cerebral ischemia. Orthologous to human KCNK2 (potassium two pore domain channel subfamily K member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 58.6), Heart (RPKM 45.7) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q26

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (103297387..103494686, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (100766101..100963435, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (107690111..107886476, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prolonged stretching of rat uteri causes hypoxia and inhibits contractility via potassium channel TREK1.
Title: Prolonged stretching of rat uteri causes hypoxia and inhibits contractility via potassium channel TREK1.
Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier.
Title: Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier.
The Role of TREK-1 and AQP5 in Gonadocorticoid-Related Voice Disorders.
Title: The Role of TREK-1 and AQP5 in Gonadocorticoid-Related Voice Disorders.
PKC- and PKA-dependent phosphorylation modulates TREK-1 function in naive and neuropathic rats.
Title: PKC- and PKA-dependent phosphorylation modulates TREK-1 function in naïve and neuropathic rats.
The transcription factor Foxd3 induces spinal cord ischemia-reperfusion injury by potentiating microRNA-214-dependent inhibition of Kcnk2.
Title: The transcription factor Foxd3 induces spinal cord ischemia-reperfusion injury by potentiating microRNA-214-dependent inhibition of Kcnk2.
we show that TREK-1 and TRAAK are clustered at nodes of Ranvier of rat trigeminal Abeta-afferent nerves with a density over 3,000-fold higher than that on their somas
Title: TREK-1 and TRAAK Are Principal K(+) Channels at the Nodes of Ranvier for Rapid Action Potential Conduction on Mammalian Myelinated Afferent Nerves.
The authors show that TREK-1 activity is involved in the bupivacaine (BPV)-induced cytotoxicity and the antagonistic effect of lipid emulsion (LE) in H9c2 rat cardiomyoblasts and suggest that TREK-1 could be a target for action of BPV and LE.
Title: Involvement of TREK-1 Channel in Cell Viability of H9c2 Rat Cardiomyoblasts Affected by Bupivacaine and Lipid Emulsion.
that miR-183-5P participated in the regulation of chronic constriction sciatic nerve injury-induced neuropathic pain through inhibiting the expression of TREK-1
Title: MiR-183-5p Alleviates Chronic Constriction Injury-Induced Neuropathic Pain Through Inhibition of TREK-1.
strong immunoreactivity of TRAAK, TREK-1 and TREK-2 channels was present mainly in small-sized dorsal root ganglion (DRG) neurons of rats.
Title: Characterization of temperature-sensitive leak K(+) currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats.
TREK-1 channel was upregulated in the DRG of DO rats after chronic partial bladder outlet obstruction, which might suppress neuronal excitability and play a protective role in bladder overactivity in PBOO.
Title: Increased Expression of TREK-1 K+ Channel in the Dorsal Root Ganglion of Rats with Detrusor Overactivity After Partial Bladder Outlet Obstruction.

Submit: New GeneRIF Correction See all GeneRIFs (38)

General gene information

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Markers

RH129439 (e-PCR)
- UniSTS:212746

Kcnk2 (e-PCR), detects polymorphism
- UniSTS:547594

RH144239 (e-PCR)
- UniSTS:233484

RH130296 (e-PCR)
- UniSTS:213582

D13Got97 (e-PCR)
- UniSTS:112270

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables ligand-gated channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated channel activity	ISO Inferred from Sequence Orthology more info
enables mechanosensitive potassium channel activity	ISO Inferred from Sequence Orthology more info
enables mechanosensitive potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables outward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium ion leak channel activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium ion leak channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cardiac ventricle development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to arachidonate	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemical synaptic transmission, postsynaptic	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cochlea development	IEP Inferred from Expression Pattern more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutamate secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in memory	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, GABAergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in calyx of Held	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in node of Ranvier	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium channel subfamily K member 2

Names: TREK-1 K(+) channel subunit; arachidonic acid sensitive tandem pore domain potassium channel; ion transport membrane protein; outward rectifying potassium channel protein TREK-1; potassium channel, two pore domain subfamily K, member 2; stretch-activated potassium channel TREK-1; tandem-pore-domain potassium channel TREK-1; two pore domain potassium channel TREK-1; two pore potassium channel TPKC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.