Acacb acetyl-CoA carboxylase beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acacbprovided by RGD
Official Full Name: acetyl-CoA carboxylase betaprovided by RGD
Primary source: RGD:620500
See related: EnsemblRapid:ENSRNOG00000000658 AllianceGenome:RGD:620500
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Acc2
Summary: Enables biotin binding activity. Involved in several processes, including carboxylic acid metabolic process; intracellular aspartate homeostasis; and intracellular glutamate homeostasis. Part of mitochondrial fatty acid beta-oxidation multienzyme complex. Used to study steatotic liver disease. Biomarker of metabolic dysfunction-associated steatotic liver disease and obesity. Orthologous to human ACACB (acetyl-CoA carboxylase beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 318.0), Muscle (RPKM 203.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 59

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (48026394..48138214, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (42365800..42477651, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (48127149..48238969, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The hexosamine biosynthetic pathway induces gene promoter activity of acetyl-CoA carboxylase beta in myoblasts.
Title: The hexosamine biosynthetic pathway induces gene promoter activity of acetyl-CoA carboxylase beta.
highlight site-specific impacts of hypothalamic acetyl-CoA carboxylase activation in leptin's anorectic signaling cascade.
Title: Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake.
data support a potential role for Acetyl-CoA carboxylases (ACC) 1 and 2 in the development of obesity and diabetes in rats; results point towards major differences in ACC tissue distribution between humans and rats
Title: Acetyl-CoA carboxylases 1 and 2 show distinct expression patterns in rats and humans and alterations in obesity and diabetes.
Human leptin increased AMP-activated protein kinase-alpha and Acacb phosphorylation in rat skeletal muscle of lean, but not obese rats.
Title: AMPK and ACC phosphorylation: effect of leptin, muscle fibre type and obesity.
study provides evidence that acetyl-CoA carboxylase beta expression in liver is regulated at the transcriptional level by the direct interaction of sterol regulatory element binding protein-1 with promoter II
Title: Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver.
Acc regulation in rat in response to exercise
Title: Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise.
differential regulation of ACCbeta gene expression between tissues
Title: Alternative usages of multiple promoters of the acetyl-CoA carboxylase beta gene are related to differential transcriptional regulation in human and rodent tissues.
Skeletal muscle ACC is more potently inhibited by palmitoyl-CoA after having been phosphorylated by AMPK.
Title: Effect of phosphorylation by AMP-activated protein kinase on palmitoyl-CoA inhibition of skeletal muscle acetyl-CoA carboxylase.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA carboxylase activity	ISO Inferred from Sequence Orthology more info
enables biotin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acetyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular aspartate homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular glutamate homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lactic acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in malonyl-CoA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in malonyl-CoA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in pentose-phosphate shunt	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heart growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in purine nucleotide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle hypertrophy in response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in tricarboxylic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of mitochondrial fatty acid beta-oxidation multienzyme complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acetyl-CoA carboxylase 2

Names: acetyl-Coenzyme A carboxylase 2; acetyl-Coenzyme A carboxylase beta

NP_446374.2

EC 6.4.1.2

XP_017453731.1

EC 6.4.1.2

XP_017453732.1

EC 6.4.1.2

XP_017453734.1

EC 6.4.1.2

XP_017453735.1

EC 6.4.1.2

XP_017453736.1

EC 6.4.1.2

XP_017453737.1

EC 6.4.1.2

XP_038944959.1

EC 6.4.1.2

XP_063127084.1

EC 6.4.1.2

XP_063127085.1

EC 6.4.1.2

XP_063127086.1

EC 6.4.1.2

XP_063127087.1

EC 6.4.1.2

XP_063127088.1

EC 6.4.1.2

XP_063127089.1

EC 6.4.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053922.2 → NP_446374.2 acetyl-CoA carboxylase 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

Q1HEC0

Related

ENSRNOP00000060736.2, ENSRNOT00000067975.6

Conserved Domains (4) summary

COG0439
Location:257 → 760

AccC; Biotin carboxylase [Lipid transport and metabolism]

pfam00364
Location:892 → 958

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1777 → 2331

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:959 → 1685

ACC_central; Acetyl-CoA carboxylase, central region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

48026394..48138214 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271014.1 → XP_063127084.1 acetyl-CoA carboxylase 2 isoform X3

UniProtKB/TrEMBL

A0A0G2K5L6, Q1HEC0

Related

ENSRNOP00000073473.2, ENSRNOT00000080557.3
XM_017598246.3 → XP_017453735.1 acetyl-CoA carboxylase 2 isoform X2

UniProtKB/TrEMBL

A0A0G2K1F2, Q1HEC0
XM_017598242.3 → XP_017453731.1 acetyl-CoA carboxylase 2 isoform X1

UniProtKB/TrEMBL

Q1HEC0

Related

ENSRNOP00000071816.3, ENSRNOT00000078868.3
XM_017598243.3 → XP_017453732.1 acetyl-CoA carboxylase 2 isoform X1

UniProtKB/TrEMBL

Q1HEC0
XM_063271016.1 → XP_063127086.1 acetyl-CoA carboxylase 2 isoform X4

UniProtKB/TrEMBL

Q1HEC0
XM_063271015.1 → XP_063127085.1 acetyl-CoA carboxylase 2 isoform X2

UniProtKB/TrEMBL

A0A0G2K1F2, Q1HEC0
XM_017598245.3 → XP_017453734.1 acetyl-CoA carboxylase 2 isoform X1

UniProtKB/TrEMBL

Q1HEC0
XM_017598247.3 → XP_017453736.1 acetyl-CoA carboxylase 2 isoform X5

UniProtKB/TrEMBL

A0A8I6ART3
XM_063271018.1 → XP_063127088.1 acetyl-CoA carboxylase 2 isoform X8

UniProtKB/TrEMBL

A0A8I6ART3
XM_063271017.1 → XP_063127087.1 acetyl-CoA carboxylase 2 isoform X7

UniProtKB/TrEMBL

A0A8I6ART3

Related

ENSRNOP00000094530.2, ENSRNOT00000113138.2
XM_017598248.3 → XP_017453737.1 acetyl-CoA carboxylase 2 isoform X6

UniProtKB/TrEMBL

A0A8I6ART3
XM_063271019.1 → XP_063127089.1 acetyl-CoA carboxylase 2 isoform X9

UniProtKB/TrEMBL

A0A8I6ART3
XM_039089031.2 → XP_038944959.1 acetyl-CoA carboxylase 2 isoform X10

Conserved Domains (3) summary

COG0439
Location:257 → 760

AccC; Biotin carboxylase [Lipid transport and metabolism]

pfam00364
Location:892 → 958

Biotin_lipoyl; Biotin-requiring enzyme

pfam08326
Location:959 → 1508

ACC_central; Acetyl-CoA carboxylase, central region