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    Yeats2 YEATS domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498112, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Yeats2provided by RGD
    Official Full Name
    YEATS domain containing 2provided by RGD
    Primary source
    RGD:1566176
    See related
    EnsemblRapid:ENSRNOG00000023107 AllianceGenome:RGD:1566176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566176
    Summary
    Predicted to enable several functions, including TBP-class protein binding activity; histone reader activity; and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of embryonic development; and regulation of tubulin deacetylation. Predicted to be located in mitotic spindle. Predicted to be part of ATAC complex and NuA4 histone acetyltransferase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 4. Orthologous to human YEATS2 (YEATS domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 105.9), Lung (RPKM 74.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Yeats2 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (94247538..94333652, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (80743134..80829253, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (84330064..84595296, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352401 Neighboring gene MAP6 domain containing 1 Neighboring gene kelch-like family member 24 Neighboring gene transfer RNA threonine (anticodon AGU) 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. YEATS2 is a selective histone crotonylation reader. Zhao D, et al. Cell Res, 2016 May. PMID 27103431, Free PMC Article
    2. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article
    3. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. Wang YL, et al. J Biol Chem, 2008 Dec 5. PMID 18838386, Free PMC Article
    4. ATAC-king the complexity of SAGA during evolution. Spedale G, et al. Genes Dev, 2012 Mar 15. PMID 22426530, Free PMC Article
    5. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. Krebs AR, et al. EMBO Rep, 2010 Jul. PMID 20508642, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ATAC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    YEATS domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109057.2 → NP_001102527.1  YEATS domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001102527.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6JSC0, D3ZBV9
      Conserved Domains (2) summary
      PHA03247
      Location:342 → 653
      PHA03247; large tegument protein UL36; Provisional
      cd16907
      Location:209 → 332
      YEATS_YEATS2_like; YEATS domain found in YEATS2 and Drosophila D12

    2. NM_001431681.1 → NP_001418610.1  YEATS domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6JSC0, D3ZBV9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      94247538..94333652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270713.1 → XP_063126783.1  YEATS domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      D3ZBV9

    2. XM_063270710.1 → XP_063126780.1  YEATS domain-containing protein 2 isoform X1

    3. XM_063270711.1 → XP_063126781.1  YEATS domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZPX3, D3ZBV9
      Related
      ENSRNOP00000080576.1, ENSRNOT00000112615.2

    4. XM_063270712.1 → XP_063126782.1  YEATS domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      D3ZBV9

    5. XM_063270709.1 → XP_063126779.1  YEATS domain-containing protein 2 isoform X1

      Related
      ENSRNOP00000062371.3, ENSRNOT00000064212.3

    6. XM_063270714.1 → XP_063126784.1  YEATS domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      D3ZBV9
    Nucleotide Protein Strain
    Heading Accession and Version

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