Hira histone cell cycle regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Hiraprovided by RGD
Full Name: histone cell cycle regulatorprovided by RGD
Primary source: RGD:1584950
See related: EnsemblRapid:ENSRNOG00000045770 AllianceGenome:RGD:1584950
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and histone binding activity. Predicted to contribute to nucleosome binding activity. Predicted to be involved in nucleosome assembly. Predicted to act upstream of or within gastrulation; muscle cell differentiation; and osteoblast differentiation. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of HIR complex. Orthologous to human HIRA (histone cell cycle regulator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 58.7), Thymus (RPKM 53.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (95528831..95637565, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (82024469..82133212, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (86168196..86276430, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D11Got81 (e-PCR)
- UniSTS:113434

BE115254 (e-PCR)
- UniSTS:261462

D22S1095E (e-PCR)
- UniSTS:153811

D22S1039 (e-PCR)
- UniSTS:151775

Hira (e-PCR), detects polymorphism
- UniSTS:143346

Hira (e-PCR), detects polymorphism
- UniSTS:265717

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
contributes_to nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gastrulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of HIR complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein HIRA

Names: HIR histone cell cycle regulation defective homolog A; histone cell cycle regulation defective homolog A; protein HIRA-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135760.1 → NP_001129232.1 protein HIRA

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

M0R4R2

Related

ENSRNOP00000064357.1, ENSRNOT00000075164.3

Conserved Domains (5) summary

COG2319
Location:7 → 372

WD40; WD40 repeat [General function prediction only]

cd00200
Location:7 → 352

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam07569
Location:761 → 952

Hira; TUP1-like enhancer of split

pfam09453
Location:448 → 469

HIRA_B; HIRA B motif

sd00039
Location:16 → 61

7WD40; WD40 repeat [structural motif]