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    Vps26c VPS26 endosomal protein sorting factor C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360703, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps26cprovided by RGD
    Official Full Name
    VPS26 endosomal protein sorting factor Cprovided by RGD
    Primary source
    RGD:1306879
    See related
    EnsemblRapid:ENSRNOG00000001681 AllianceGenome:RGD:1306879
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dscr3
    Summary
    Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to be active in endosome. Orthologous to human VPS26C (VPS26 endosomal protein sorting factor C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 96.6), Adrenal (RPKM 95.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vps26c in Genome Data Viewer
    Location:
    11q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (47283764..47311105, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (33813467..33841883, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (34764053..34792446, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class P Neighboring gene tetratricopeptide repeat domain 3 Neighboring gene U1 spliceosomal RNA Neighboring gene large ribosomal subunit protein uL5-like Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 1A Neighboring gene uncharacterized LOC120095638

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. McNally KE, et al. Nat Cell Biol, 2017 Oct. PMID 28892079, Free PMC Article
    2. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting-associated protein 26C
    Names
    DSCR3 arrestin fold containing
    Down syndrome critical region 3
    Down syndrome critical region gene 3
    Down syndrome critical region protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108316.2 → NP_001101786.2  vacuolar protein sorting-associated protein 26C

      See identical proteins and their annotated locations for NP_001101786.2

      Status: PROVISIONAL

      Source sequence(s)
      BC160826
      UniProtKB/TrEMBL
      A0A8I6A9V7, B1H223
      Related
      ENSRNOP00000002284.6, ENSRNOT00000002284.8
      Conserved Domains (1) summary
      cl22903
      Location:1 → 283
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      47283764..47311105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270630.1 → XP_063126700.1  vacuolar protein sorting-associated protein 26C isoform X4

    2. XM_006248072.5 → XP_006248134.1  vacuolar protein sorting-associated protein 26C isoform X2

      UniProtKB/TrEMBL
      A0A8I6A639
      Related
      ENSRNOP00000088383.1, ENSRNOT00000112054.2
      Conserved Domains (1) summary
      cl22903
      Location:1 → 233
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    3. XM_039088476.2 → XP_038944404.1  vacuolar protein sorting-associated protein 26C isoform X3

      Conserved Domains (1) summary
      cl22903
      Location:1 → 176
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    4. XM_008768583.4 → XP_008766805.1  vacuolar protein sorting-associated protein 26C isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9V7
      Conserved Domains (1) summary
      cl22903
      Location:1 → 261
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    5. XM_039088477.2 → XP_038944405.1  vacuolar protein sorting-associated protein 26C isoform X5

      UniProtKB/TrEMBL
      A6KPW2
      Conserved Domains (1) summary
      cl22903
      Location:1 → 169
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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