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    Thap7 THAP domain containing 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287944, updated on 9-Dec-2024

    Summary

    Official Symbol
    Thap7provided by RGD
    Official Full Name
    THAP domain containing 7provided by RGD
    Primary source
    RGD:1308061
    See related
    EnsemblRapid:ENSRNOG00000037967 AllianceGenome:RGD:1308061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including C2H2 zinc finger domain binding activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in chromatin organization and negative regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; nuclear membrane; and nuclear speck. Predicted to be active in nucleus. Orthologous to human THAP7 (THAP domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 51.1), Kidney (RPKM 48.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Thap7 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96986720..96990375)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83482958..83486136)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87399430..87403381, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X 6 Neighboring gene leucine rich repeat containing 74B Neighboring gene translation machinery-associated protein 16 pseudogene Neighboring gene leucine zipper like post translational regulator 1 Neighboring gene AIF family member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C2H2 zinc finger domain binding  
    enables DNA binding  
    enables general transcription initiation factor binding  
    enables histone binding  
    enables histone deacetylase binding  
    enables histone reader activity  
    enables identical protein binding  
    enables lysine-acetylated histone binding  
    enables methylated histone binding  
    enables phosphorylated histone binding  
    enables transcription corepressor binding  
    Component Evidence Code Pubs
    located_in chromatin  
    located_in intracellular membrane-bounded organelle  
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nuclear speck  
    located_in nucleoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    THAP domain-containing protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105863.2 → NP_001099333.2  THAP domain-containing protein 7

      See identical proteins and their annotated locations for NP_001099333.2

      Status: VALIDATED

      Source sequence(s)
      AW916308, BC168998
      UniProtKB/TrEMBL
      A0A8I6AQX2, A0A8I6B5E1, A6JSL3
      Related
      ENSRNOP00000097153.1, ENSRNOT00000116617.2
      Conserved Domains (1) summary
      smart00980
      Location:4 → 93
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96986720..96990375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088075.2 → XP_038944003.1  THAP domain-containing protein 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AQX2
      Conserved Domains (1) summary
      smart00980
      Location:4 → 108
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
    2. XM_063270324.1 → XP_063126394.1  THAP domain-containing protein 7 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AQX2
    3. XM_008768864.3 → XP_008767086.2  THAP domain-containing protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQX2, G3V9P2
      Conserved Domains (1) summary
      smart00980
      Location:4 → 127
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
    4. XM_063270325.1 → XP_063126395.1  THAP domain-containing protein 7 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AQX2
    5. XM_039088076.2 → XP_038944004.1  THAP domain-containing protein 7 isoform X6

    6. XM_039088074.2 → XP_038944002.1  THAP domain-containing protein 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQX2
      Related
      ENSRNOP00000054562.4, ENSRNOT00000057751.6
      Conserved Domains (1) summary
      smart00980
      Location:4 → 125
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
    7. XM_039088077.2 → XP_038944005.1  THAP domain-containing protein 7 isoform X7

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