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    Ska2 spindle and kinetochore associated complex subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287598, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ska2provided by RGD
    Official Full Name
    spindle and kinetochore associated complex subunit 2provided by RGD
    Primary source
    RGD:1307084
    See related
    EnsemblRapid:ENSRNOG00000025981 AllianceGenome:RGD:1307084
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam33a; RGD1307084
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in establishment of meiotic spindle orientation; nuclear chromosome segregation; and regulation of microtubule polymerization or depolymerization. Predicted to be located in kinetochore and meiotic spindle. Predicted to be part of SKA complex. Predicted to be active in spindle microtubule. Orthologous to human SKA2 (spindle and kinetochore associated complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 112.8), Heart (RPKM 84.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ska2 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (72418707..72436721)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (71921474..71939461)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (74413989..74431922)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glycerophosphodiester phosphodiesterase domain containing 1 Neighboring gene interferon induced transmembrane protein 1, pseudogene 1 Neighboring gene uncharacterized LOC120095167 Neighboring gene SMG8 nonsense mediated mRNA decay factor Neighboring gene proline rich 11 Neighboring gene microRNA 301a Neighboring gene tripartite motif-containing 37 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1E Neighboring gene uncharacterized LOC134480846

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. Hanisch A, et al. EMBO J, 2006 Nov 29. PMID 17093495, Free PMC Article
    2. The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. Welburn JP, et al. Dev Cell, 2009 Mar. PMID 19289083, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109093

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in attachment of mitotic spindle microtubules to kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of meiotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of meiotic spindle orientation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spindle assembly involved in female meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle assembly involved in female meiosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SKA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in meiotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in meiotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of outer kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of outer kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SKA complex subunit 2; spindle and kinetochore-associated protein 2
    Names
    family with sequence similarity 33, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009624.1 → NP_001009624.1  SKA complex subunit 2

      See identical proteins and their annotated locations for NP_001009624.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088264
      UniProtKB/Swiss-Prot
      A6HHS9, Q5I0J4
      Related
      ENSRNOP00000033780.3, ENSRNOT00000036098.5
      Conserved Domains (1) summary
      cl17165
      Location:5 → 120
      SKA2; Spindle and kinetochore-associated protein 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      72418707..72436721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085562.2 → XP_038941490.1  spindle and kinetochore-associated protein 2 isoform X1

      Conserved Domains (1) summary
      cl17165
      Location:2 → 57
      SKA2; Spindle and kinetochore-associated protein 2

    RNA

    1. XR_010055156.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5I0J4.1 GenPept UniProtKB/Swiss-Prot:Q5I0J4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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