Nlrp5 NLR family, pyrin domain containing 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nlrp5provided by RGD
Official Full Name: NLR family, pyrin domain containing 5provided by RGD
Primary source: RGD:1307446
See related: AllianceGenome:RGD:1307446
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nalp5
Summary: Predicted to enable tubulin binding activity. Predicted to be involved in several processes, including cortical granule exocytosis; cytoskeleton organization; and positive regulation of embryonic development. Predicted to act upstream of or within several processes, including embryo implantation; regulation of RNA stability; and regulation of protein stability. Predicted to be located in several cellular components, including apical cortex; cortical granule; and ooplasm. Predicted to be part of subcortical maternal complex. Predicted to be active in several cellular components, including cell cortex; cytosol; and mitochondrion. Orthologous to human NLRP5 (NLR family pyrin domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 1.4), Adrenal (RPKM 1.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (76811044..76872964, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (67778037..67810941, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (71452184..71490915, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that NALP1 and NALP5 may regulate caspase activation and apoptosis in injured neurons.
Title: Induced expression of death domain genes NALP1 and NALP5 following neuronal injury.

Submit: New GeneRIF Correction

General gene information

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Markers

Nlrp5 (e-PCR), detects polymorphism
- UniSTS:526828

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cortical granule exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in establishment of organelle localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of spindle localization	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fertilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of RNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical cortex	ISO Inferred from Sequence Orthology more info
part_of canonical inflammasome complex	IEA Inferred from Electronic Annotation more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cortical granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in ooplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of subcortical maternal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of subcortical maternal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 5

Names: NACHT, leucine rich repeat and PYD containing 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

76811044..76872964 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063280572.1 → XP_063136642.1 NACHT, LRR and PYD domains-containing protein 5

UniProtKB/TrEMBL

A0A8I6ALL1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107474.1: Suppressed sequence

Description

NM_001107474.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.