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Kcnq1 potassium voltage-gated channel subfamily Q member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84020, updated on 9-Dec-2024

Summary

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Official Symbol: Kcnq1provided by RGD
Official Full Name: potassium voltage-gated channel subfamily Q member 1provided by RGD
Primary source: RGD:621503
See related: EnsemblRapid:ENSRNOG00000020532 AllianceGenome:RGD:621503
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kvlqt1
Summary: Enables delayed rectifier potassium channel activity; identical protein binding activity; and outward rectifier potassium channel activity. Involved in several processes, including male gonad development; negative regulation of insulin secretion; and response to anesthetic. Located in basolateral plasma membrane; sarcolemma; and zymogen granule membrane. Part of voltage-gated potassium channel complex. Used to study hypertension and long QT syndrome. Human ortholog(s) of this gene implicated in heart conduction disease (multiple); long QT syndrome (multiple); and type 2 diabetes mellitus. Orthologous to human KCNQ1 (potassium voltage-gated channel subfamily Q member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 171.6), Kidney (RPKM 83.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Kcnq1 in Genome Data Viewer

Location:: 1q42

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (207721134..208054073)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (198291711..198624683)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (216293087..216630339)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Membrane pools of phosphatidylinositol-4-phosphate regulate KCNQ1/KCNE1 membrane expression.
Title: Membrane pools of phosphatidylinositol-4-phosphate regulate KCNQ1/KCNE1 membrane expression.
KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea.
Title: KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea.
The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function.
Title: The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function.
Smooth muscle cell contractility was inhibited by treatment with a KCNQ1 inhibitor.
Title: KCNQ1 variants associate with hypertension in type 2 diabetes and affect smooth muscle contractility in vitro.
Downregulated pulmonary expression of KCNQ5 in rat nitrofen-induced congenital diaphragmatic hernia lungs suggests that this potassium channel may play an important role in the development of pulmonary hypertension in this model. KCNQ1 and KCNQ4 expression was not altered.
Title: Downregulation of KCNQ5 expression in the rat pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia.
In adult ventricular myocytes, KCNE1 maintains a stable presence on the cell surface, whereas KCNQ1 is dynamic in its localization. KCNQ1 is largely in an intracellular reservoir under basal conditions but can traffic to the cell surface and boost the IKs amplitude in response to stress.
Title: Adult Ventricular Myocytes Segregate KCNQ1 and KCNE1 to Keep the I(Ks) Amplitude in Check Until When Larger I(Ks) Is Needed.
Activation of PPARbeta/delta prevents hyperglycaemia-induced impairment of Kv7 channels.
Title: Activation of PPARβ/δ prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries.
KV channel expression and activity were upregulated after YM155 treatment. Survivin may play a role in the pathogenesis of CH-PH.
Title: YM155, a selective survivin inhibitor, reverses chronic hypoxic pulmonary hypertension in rats via upregulating voltage-gated potassium channels.
The high expression and function of Kv7 channels in the left coronary artery and their down-regulation by diabetes critically determine the sensitivity to key regulators of coronary tone.
Title: Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia.
Kv7.1/Kv7.5 form heterotetrameric channels increasing the diversity of structures which fine-tune blood vessel reactivity. The lipid raft localization of Kv7.1/Kv7.5 heteromers provides efficient spatial and temporal regulation of smooth muscle function.
Title: Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU047338 (e-PCR)
- UniSTS:110606

AU047567 (e-PCR)
- UniSTS:110381

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:143678

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:143680

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:143681

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:143682

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:143683

AA964210 (e-PCR)
- UniSTS:248419

BE120633 (e-PCR)
- UniSTS:247398

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:463213

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:516464

BF389163 (e-PCR)
- UniSTS:245393

D1Wox9 (e-PCR)
- UniSTS:117941

AU049425 (e-PCR)
- UniSTS:145872

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:256980

RH134033 (e-PCR)
- UniSTS:217315

UniSTS:465396 (e-PCR)
- UniSTS:465396

Kcnq1ot1 (e-PCR), detects polymorphism
- UniSTS:465396

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:265461

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables delayed rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
contributes_to delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables outward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A catalytic subunit binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A catalytic subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 1 binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info
contributes_to voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in auditory receptor cell development	IEA Inferred from Electronic Annotation more info
involved_in auditory receptor cell development	ISO Inferred from Sequence Orthology more info
involved_in cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epinephrine stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to epinephrine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in chloride ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cochlea development	IEA Inferred from Electronic Annotation more info
involved_in cochlea development	ISO Inferred from Sequence Orthology more info
involved_in corticosterone secretion	IEA Inferred from Electronic Annotation more info
involved_in corticosterone secretion	ISO Inferred from Sequence Orthology more info
involved_in detection of mechanical stimulus involved in sensory perception of sound	IEA Inferred from Electronic Annotation more info
involved_in detection of mechanical stimulus involved in sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within digestive system process	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in gastric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in gastrin-induced gastric acid secretion	IEA Inferred from Electronic Annotation more info
involved_in gastrin-induced gastric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
involved_in inner ear development	ISO Inferred from Sequence Orthology more info
involved_in inner ear development	ISS Inferred from Sequence or Structural Similarity more info
involved_in inner ear morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in intestinal absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular chloride ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular chloride ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in iodide transport	IEA Inferred from Electronic Annotation more info
involved_in iodide transport	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane repolarization during action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during atrial cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane repolarization during atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during ventricular cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane repolarization during ventricular cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within membrane repolarization during ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in non-motile cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of atrial cardiac muscle cell membrane repolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of atrial cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of gastric acid secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of gastric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of gastric acid secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of transporter activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of voltage-gated sodium channel activity	ISO Inferred from Sequence Orthology more info
involved_in renal absorption	ISO Inferred from Sequence Orthology more info
involved_in renal absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in renal sodium ion absorption	IEA Inferred from Electronic Annotation more info
involved_in renal sodium ion absorption	ISO Inferred from Sequence Orthology more info
involved_in response to anesthetic	IDA Inferred from Direct Assay more info	PubMed
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	ISO Inferred from Sequence Orthology more info
involved_in rhythmic behavior	IEA Inferred from Electronic Annotation more info
involved_in rhythmic behavior	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in social behavior	IEA Inferred from Electronic Annotation more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in stomach development	IEA Inferred from Electronic Annotation more info
involved_in stomach development	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral part of cell	IEA Inferred from Electronic Annotation more info
is_active_in basolateral part of cell	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ciliary base	IEA Inferred from Electronic Annotation more info
is_active_in ciliary base	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lumenal side of membrane	IEA Inferred from Electronic Annotation more info
located_in lumenal side of membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
part_of monoatomic ion channel complex	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle	IEA Inferred from Electronic Annotation more info
is_active_in transport vesicle	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
located_in zymogen granule membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: potassium voltage-gated channel subfamily KQT member 1

Names: IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; potassium channel, voltage-gated KQT-like subfamily Q, member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; voltage-gated potassium channel subunit Kv7.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032073.2 → NP_114462.2 potassium voltage-gated channel subfamily KQT member 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O08655, Q9Z0N7

UniProtKB/TrEMBL

A6HYA9, F1LMY9

Related

ENSRNOP00000027875.6, ENSRNOT00000027875.9

Conserved Domains (2) summary

pfam00520
Location:123 → 359

Ion_trans; Ion transport protein

pfam03520
Location:511 → 617

KCNQ_channel; KCNQ voltage-gated potassium channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

207721134..208054073

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092713.2 → XP_038948641.1 potassium voltage-gated channel subfamily KQT member 1 isoform X3

UniProtKB/TrEMBL

A0A8I5ZN79

Conserved Domains (1) summary

pfam00520
Location:123 → 359

Ion_trans; Ion transport protein
XM_039092720.2 → XP_038948648.1 potassium voltage-gated channel subfamily KQT member 1 isoform X4

UniProtKB/TrEMBL

A0A8I5ZN79

Conserved Domains (1) summary

pfam00520
Location:123 → 359

Ion_trans; Ion transport protein
XM_039092725.2 → XP_038948653.1 potassium voltage-gated channel subfamily KQT member 1 isoform X5

UniProtKB/TrEMBL

A0A8I5ZN79

Related

ENSRNOP00000074437.3, ENSRNOT00000087153.3

Conserved Domains (1) summary

pfam00520
Location:123 → 359

Ion_trans; Ion transport protein
XM_039092702.2 → XP_038948630.1 potassium voltage-gated channel subfamily KQT member 1 isoform X1

UniProtKB/Swiss-Prot

O08655, Q9Z0N7

Conserved Domains (2) summary

pfam00520
Location:123 → 359

Ion_trans; Ion transport protein

pfam03520
Location:511 → 585

KCNQ_channel; KCNQ voltage-gated potassium channel
XM_039092705.2 → XP_038948633.1 potassium voltage-gated channel subfamily KQT member 1 isoform X2

UniProtKB/TrEMBL

A0A8I6AHW5

Related

ENSRNOP00000079530.2, ENSRNOT00000076661.3

Conserved Domains (2) summary

pfam00520
Location:123 → 359

Ion_trans; Ion transport protein

pfam03520
Location:511 → 587

KCNQ_channel; KCNQ voltage-gated potassium channel
XM_039092732.2 → XP_038948660.1 potassium voltage-gated channel subfamily KQT member 1 isoform X6

Conserved Domains (1) summary

pfam03520
Location:208 → 314

KCNQ_channel; KCNQ voltage-gated potassium channel