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    Apba2 amyloid beta precursor protein binding family A member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83610, updated on 9-Dec-2024

    Summary

    Official Symbol
    Apba2provided by RGD
    Official Full Name
    amyloid beta precursor protein binding family A member 2provided by RGD
    Primary source
    RGD:620845
    See related
    EnsemblRapid:ENSRNOG00000016358 AllianceGenome:RGD:620845
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mint2
    Summary
    Enables amyloid-beta binding activity. Predicted to be involved in chemical synaptic transmission and presynaptic modulation of chemical synaptic transmission. Predicted to act upstream of or within in utero embryonic development; locomotory behavior; and regulation of gene expression. Is active in presynapse. Orthologous to human APBA2 (amyloid beta precursor protein binding family A member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 244.4), Testes (RPKM 45.7) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Apba2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (127465026..127698124)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (118053270..118286858)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (125367273..125547741)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene M-phase phosphoprotein 10 Neighboring gene methylmalonyl CoA epimerase Neighboring gene uncharacterized LOC134483612 Neighboring gene uncharacterized LOC120097338 Neighboring gene endosomal transmembrane epsin interactor 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene NSE3 homolog, SMC5-SMC6 complex component

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables amyloid-beta binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    amyloid-beta A4 precursor protein-binding family A member 2
    Names
    adapter protein X11beta
    amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like)
    neuron-specific X11L protein
    neuronal Munc18-1-interacting protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031780.2NP_113968.1  amyloid-beta A4 precursor protein-binding family A member 2

      See identical proteins and their annotated locations for NP_113968.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O35431
      UniProtKB/TrEMBL
      A6JBL8
      Conserved Domains (4) summary
      cd00992
      Location:658731
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01208
      Location:364536
      PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
      pfam00595
      Location:569652
      PDZ; PDZ domain (Also known as DHR or GLGF)
      NF033845
      Location:20303
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      127465026..127698124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092566.2XP_038948494.1  amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

      UniProtKB/Swiss-Prot
      O35431
      UniProtKB/TrEMBL
      A6JBL8
      Related
      ENSRNOP00000022049.5, ENSRNOT00000022049.8
      Conserved Domains (4) summary
      cd00992
      Location:658731
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01208
      Location:364536
      PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
      pfam00595
      Location:569652
      PDZ; PDZ domain (Also known as DHR or GLGF)
      NF033845
      Location:20303
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    2. XM_063275521.1XP_063131591.1  amyloid-beta A4 precursor protein-binding family A member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKT7
    3. XM_063275507.1XP_063131577.1  amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

      UniProtKB/Swiss-Prot
      O35431
      UniProtKB/TrEMBL
      A6JBL8
    4. XM_039092570.2XP_038948498.1  amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

      UniProtKB/Swiss-Prot
      O35431
      UniProtKB/TrEMBL
      A6JBL8
      Conserved Domains (4) summary
      cd00992
      Location:658731
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01208
      Location:364536
      PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
      pfam00595
      Location:569652
      PDZ; PDZ domain (Also known as DHR or GLGF)
      NF033845
      Location:20303
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    5. XM_063275551.1XP_063131621.1  amyloid-beta A4 precursor protein-binding family A member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKT7
    6. XM_039092563.2XP_038948491.1  amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

      UniProtKB/Swiss-Prot
      O35431
      UniProtKB/TrEMBL
      A6JBL8
      Conserved Domains (4) summary
      cd00992
      Location:658731
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01208
      Location:364536
      PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
      pfam00595
      Location:569652
      PDZ; PDZ domain (Also known as DHR or GLGF)
      NF033845
      Location:20303
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    7. XM_039092574.2XP_038948502.1  amyloid-beta A4 precursor protein-binding family A member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKT7
      Conserved Domains (3) summary
      cd01208
      Location:364524
      PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
      pfam00595
      Location:650721
      PDZ; PDZ domain (Also known as DHR or GLGF)
      NF033845
      Location:20303
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    8. XM_039092571.2XP_038948499.1  amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

      UniProtKB/Swiss-Prot
      O35431
      UniProtKB/TrEMBL
      A6JBL8
      Conserved Domains (4) summary
      cd00992
      Location:658731
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01208
      Location:364536
      PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
      pfam00595
      Location:569652
      PDZ; PDZ domain (Also known as DHR or GLGF)
      NF033845
      Location:20303
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    9. XM_063275530.1XP_063131600.1  amyloid-beta A4 precursor protein-binding family A member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKT7
    10. XM_039092568.2XP_038948496.1  amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

      UniProtKB/Swiss-Prot
      O35431
      UniProtKB/TrEMBL
      A6JBL8
      Conserved Domains (4) summary
      cd00992
      Location:658731
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01208
      Location:364536
      PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
      pfam00595
      Location:569652
      PDZ; PDZ domain (Also known as DHR or GLGF)
      NF033845
      Location:20303
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    11. XM_063275517.1XP_063131587.1  amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

      UniProtKB/Swiss-Prot
      O35431
      UniProtKB/TrEMBL
      A6JBL8
    12. XM_063275541.1XP_063131611.1  amyloid-beta A4 precursor protein-binding family A member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKT7
      Related
      ENSRNOP00000093806.1, ENSRNOT00000107834.2
    13. XM_063275562.1XP_063131632.1  amyloid-beta A4 precursor protein-binding family A member 2 isoform X3