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    Cfap119 cilia and flagella associated protein 119 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691909, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cfap119provided by RGD
    Official Full Name
    cilia and flagella associated protein 119provided by RGD
    Primary source
    RGD:1593368
    See related
    EnsemblRapid:ENSRNOG00000053015 AllianceGenome:RGD:1593368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc189; Spergen-4
    Summary
    Located in acrosomal vesicle and sperm principal piece. Orthologous to human CFAP119 (cilia and flagella associated protein 119). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 150.4), Lung (RPKM 40.5) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cfap119 in Genome Data Viewer
    Location:
    1q37
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191627662..191647429, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182197171..182216936, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199032105..199037267, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Snf2-related CREBBP activator protein Neighboring gene transmembrane protein 265 Neighboring gene phosphorylase kinase catalytic subunit gamma 2 Neighboring gene ring finger protein 40 Neighboring gene zinc finger protein 629 Neighboring gene 5S ribosomal RNA Neighboring gene BAF chromatin remodeling complex subunit BCL7C Neighboring gene microRNA 762

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular Cloning of Spergen-4, Encoding a Spermatogenic Cell-Specific Protein Associated with Sperm Flagella and the Acrosome Region in Rat Spermatozoa. Howida A, et al. Zoolog Sci, 2016 Apr. PMID 27032685
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggest that Spergen-4 integrated into elongated spermatids during spermiogenesis serves as a constituent for acrosome region and flagella of rat spermatozoa.
      Title: Molecular Cloning of Spergen-4, Encoding a Spermatogenic Cell-Specific Protein Associated with Sperm Flagella and the Acrosome Region in Rat Spermatozoa.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sperm flagellum assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of radial spoke ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cilia- and flagella-associated protein 119
    Names
    coiled-coil domain containing 189
    coiled-coil domain-containing protein 189
    coiled-coil domain-containing protein C16orf93 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134694.2 → NP_001128166.2  cilia- and flagella-associated protein 119

      See identical proteins and their annotated locations for NP_001128166.2

      Status: VALIDATED

      Source sequence(s)
      BC158625
      UniProtKB/Swiss-Prot
      A0A0H5BIB4, B0BMZ6, F1LNM9
      UniProtKB/TrEMBL
      A6I9R7
      Conserved Domains (1) summary
      pfam14769
      Location:130 → 224
      CLAMP; Flagellar C1a complex subunit C1a-32

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      191627662..191647429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091721.1 → XP_038947649.1  cilia- and flagella-associated protein 119 isoform X5

      Conserved Domains (1) summary
      pfam14769
      Location:50 → 146
      CLAMP; Flagellar C1a complex subunit C1a-32

    2. XM_039091696.2 → XP_038947624.1  cilia- and flagella-associated protein 119 isoform X1

      Conserved Domains (1) summary
      pfam14769
      Location:207 → 261
      CLAMP; Flagellar C1a complex subunit C1a-32

    3. XM_039091718.2 → XP_038947646.1  cilia- and flagella-associated protein 119 isoform X4

    4. XM_039091703.2 → XP_038947631.1  cilia- and flagella-associated protein 119 isoform X2

      Conserved Domains (1) summary
      pfam14769
      Location:207 → 240
      CLAMP; Flagellar C1a complex subunit C1a-32

    5. XM_039091713.2 → XP_038947641.1  cilia- and flagella-associated protein 119 isoform X3

      Conserved Domains (1) summary
      pfam14769
      Location:207 → 261
      CLAMP; Flagellar C1a complex subunit C1a-32

    RNA

    1. XR_005492914.2 RNA Sequence

    2. XR_005492910.2 RNA Sequence

      Related
      ENSRNOT00000098454.2

    3. XR_005492915.2 RNA Sequence

    4. XR_005492911.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0BMZ6.1 GenPept UniProtKB/Swiss-Prot:B0BMZ6

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