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    Zdhhc16 zinc finger DHHC-type palmitoyltransferase 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 654495, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zdhhc16provided by RGD
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 16provided by RGD
    Primary source
    RGD:1591893
    See related
    EnsemblRapid:ENSRNOG00000046530 AllianceGenome:RGD:1591893
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable palmitoyltransferase activity. Predicted to be involved in several processes, including eye development; fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment; and protein palmitoylation. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Orthologous to human ZDHHC16 (zinc finger DHHC-type palmitoyltransferase 16). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 105.9), Kidney (RPKM 103.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zdhhc16 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (250694922..250706319)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (240745606..240757009)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (261179971..261191374)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphoglycerate mutase 1 Neighboring gene exosome component 1 Neighboring gene MMS19 homolog, cytosolic iron-sulfur assembly component Neighboring gene U6 spliceosomal RNA Neighboring gene ubiquitin domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A potential role for protein palmitoylation and zDHHC16 in DNA damage response. Cao N, et al. BMC Mol Biol, 2016 May 10. PMID 27159997, Free PMC Article
    2. Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade. Abrami L, et al. Elife, 2017 Aug 15. PMID 28826475, Free PMC Article
    3. Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Zhou T, et al. Proc Natl Acad Sci U S A, 2015 Dec 22. PMID 26644582, Free PMC Article
    4. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. Ohno Y, et al. Mol Biol Cell, 2012 Dec. PMID 23034182, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156465

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC16
    Names
    membrane-associated DHHC16 zinc finger protein
    probable palmitoyltransferase ZDHHC16
    zinc finger, DHHC domain containing 16
    zinc finger, DHHC-type containing 16
    NP_001034435.2
    NP_001388198.1
    NP_001388199.1
    XP_006231467.1
    XP_006231469.1
    XP_038946073.1
    XP_038946084.1
    XP_038946104.1
    XP_038946106.1
    XP_063129188.1
    XP_063129208.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039346.2 → NP_001034435.2  palmitoyltransferase ZDHHC16 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0JPI5
      Related
      ENSRNOP00000080251.2, ENSRNOT00000115815.2

    2. NM_001401269.1 → NP_001388198.1  palmitoyltransferase ZDHHC16 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6G4A8
      Related
      ENSRNOP00000097298.2, ENSRNOT00000109287.2

    3. NM_001401270.1 → NP_001388199.1  palmitoyltransferase ZDHHC16 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Related
      ENSRNOP00000109011.1, ENSRNOT00000145842.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      250694922..250706319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273138.1 → XP_063129208.1  palmitoyltransferase ZDHHC16 isoform X6

    2. XM_039090156.2 → XP_038946084.1  palmitoyltransferase ZDHHC16 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AU65
      Conserved Domains (1) summary
      pfam01529
      Location:156 → 305
      DHHC; DHHC palmitoyltransferase

    3. XM_006231405.5 → XP_006231467.1  palmitoyltransferase ZDHHC16 isoform X4

      UniProtKB/TrEMBL
      Q2TGJ3
      Conserved Domains (1) summary
      pfam01529
      Location:91 → 240
      DHHC; DHHC palmitoyltransferase

    4. XM_006231407.5 → XP_006231469.1  palmitoyltransferase ZDHHC16 isoform X5

      UniProtKB/TrEMBL
      Q2TGJ3
      Conserved Domains (1) summary
      pfam01529
      Location:91 → 224
      DHHC; DHHC palmitoyltransferase

    5. XM_039090145.2 → XP_038946073.1  palmitoyltransferase ZDHHC16 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G4A8, Q2TGJ3
      Related
      ENSRNOP00000066326.2, ENSRNOT00000072181.3
      Conserved Domains (1) summary
      pfam01529
      Location:156 → 305
      DHHC; DHHC palmitoyltransferase

    6. XM_063273118.1 → XP_063129188.1  palmitoyltransferase ZDHHC16 isoform X2

      UniProtKB/TrEMBL
      A0JPI5

    7. XM_039090176.2 → XP_038946104.1  palmitoyltransferase ZDHHC16 isoform X7

      UniProtKB/TrEMBL
      A6JH97
      Conserved Domains (1) summary
      pfam01529
      Location:1 → 125
      DHHC; DHHC palmitoyltransferase

    8. XM_039090178.2 → XP_038946106.1  palmitoyltransferase ZDHHC16 isoform X7

      UniProtKB/TrEMBL
      A6JH97
      Conserved Domains (1) summary
      pfam01529
      Location:1 → 125
      DHHC; DHHC palmitoyltransferase

    RNA

    1. XR_005492011.2 RNA Sequence

    2. XR_010057365.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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