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    Ech1 enoyl-CoA hydratase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64526, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ech1provided by RGD
    Official Full Name
    enoyl-CoA hydratase 1provided by RGD
    Primary source
    RGD:69353
    See related
    EnsemblRapid:ENSRNOG00000020308 AllianceGenome:RGD:69353
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pxel
    Summary
    Predicted to enable delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Orthologous to human ECH1 (enoyl-CoA hydratase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 3119.7), Muscle (RPKM 1008.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ech1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93241076..93248314)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84114494..84120788)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (87009798..87015996)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene uncharacterized LOC134483092 Neighboring gene heterogeneous nuclear ribonucleoprotein L Neighboring gene Ras and Rab interactor-like Neighboring gene galectin 4 Neighboring gene galectin 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution reveals the importance of aspartate and glutamate sidechains for catalysis. Modis Y, et al. Structure, 1998 Aug 15. PMID 9739087
    2. Enoyl coenzyme A hydratase 1 combats obesity and related metabolic disorders by promoting adipose tissue browning. Mao X, et al. Am J Physiol Endocrinol Metab, 2020 Mar 1. PMID 31961704
    3. Delta3,5-delta2,4-dienoyl-CoA isomerase from rat liver. Molecular characterization. Filppula SA, et al. J Biol Chem, 1998 Jan 2. PMID 9417087
    4. Isolation and characterization of rat and human cDNAs encoding a novel putative peroxisomal enoyl-CoA hydratase. FitzPatrick DR, et al. Genomics, 1995 Jun 10. PMID 7558027
    5. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. Ghosh D, et al. J Am Chem Soc, 2010 Mar 24. PMID 20178365

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
    Names
    Peroxisomal enoyl hydratase-like protein
    enoyl CoA hydratase 1, peroxisomal
    enoyl coenzyme A hydratase 1, peroxisomal
    enoyl hydratase-like protein, peroxisomal
    NP_072116.1
    XP_063128849.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022594.1 → NP_072116.1  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_072116.1

      Status: PROVISIONAL

      Source sequence(s)
      U08976
      UniProtKB/TrEMBL
      A0A8L2QF26
      Related
      ENSRNOP00000085027.2, ENSRNOT00000096349.2
      Conserved Domains (1) summary
      cl23717
      Location:53 → 317
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      93241076..93248314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272779.1 → XP_063128849.1  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q62651
      UniProtKB/TrEMBL
      A0A8L2QF26, A6J9L4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62651.2 GenPept UniProtKB/Swiss-Prot:Q62651

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