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    Kctd15 potassium channel tetramerization domain containing 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499129, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kctd15provided by RGD
    Official Full Name
    potassium channel tetramerization domain containing 15provided by RGD
    Primary source
    RGD:1583737
    See related
    EnsemblRapid:ENSRNOG00000021137 AllianceGenome:RGD:1583737
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human KCTD15 (potassium channel tetramerization domain containing 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 54.0), Muscle (RPKM 52.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kctd15 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (96395794..96411502, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (87258658..87271979, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (90506697..90522217, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099792 Neighboring gene uncharacterized LOC100910905 Neighboring gene uncharacterized LOC108349467 Neighboring gene carbohydrate sulfotransferase 8 Neighboring gene uncharacterized LOC134483097 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology. Gutierrez-Aguilar R, et al. Obesity (Silver Spring), 2012 Feb. PMID 21779089
    2. The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states. Smaldone G, et al. FEBS Lett, 2016 Jun. PMID 27152988
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein KCTD15
    Names
    potassium channel tetramerisation domain containing 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109141.1 → NP_001102611.1  BTB/POZ domain-containing protein KCTD15

      See identical proteins and their annotated locations for NP_001102611.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473979
      UniProtKB/TrEMBL
      B5DF44, F7FCN2
      Conserved Domains (1) summary
      cd18388
      Location:55 → 153
      BTB_POZ_KCTD15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      96395794..96411502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270937.1 → XP_063127007.1  BTB/POZ domain-containing protein KCTD15 isoform X1

      UniProtKB/TrEMBL
      B5DF44, F7FCN2

    2. XM_063270944.1 → XP_063127014.1  BTB/POZ domain-containing protein KCTD15 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLF8, F7FCN2

    3. XM_063270943.1 → XP_063127013.1  BTB/POZ domain-containing protein KCTD15 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLF8, F7FCN2
      Related
      ENSRNOP00000075028.3, ENSRNOT00000078598.3

    4. XM_063270942.1 → XP_063127012.1  BTB/POZ domain-containing protein KCTD15 isoform X1

      UniProtKB/TrEMBL
      B5DF44, F7FCN2

    5. XM_063270932.1 → XP_063127002.1  BTB/POZ domain-containing protein KCTD15 isoform X1

      UniProtKB/TrEMBL
      B5DF44, F7FCN2
      Related
      ENSRNOP00000028698.5, ENSRNOT00000028698.8

    6. XM_063270939.1 → XP_063127009.1  BTB/POZ domain-containing protein KCTD15 isoform X1

      UniProtKB/TrEMBL
      B5DF44, F7FCN2

    7. XM_063270941.1 → XP_063127011.1  BTB/POZ domain-containing protein KCTD15 isoform X1

      UniProtKB/TrEMBL
      B5DF44, F7FCN2

    8. XM_063270935.1 → XP_063127005.1  BTB/POZ domain-containing protein KCTD15 isoform X1

      UniProtKB/TrEMBL
      B5DF44, F7FCN2
    Nucleotide Protein Strain
    Heading Accession and Version

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