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    Nap1l4 nucleosome assembly protein 1-like 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361684, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nap1l4provided by RGD
    Official Full Name
    nucleosome assembly protein 1-like 4provided by RGD
    Primary source
    RGD:1305391
    See related
    EnsemblRapid:ENSRNOG00000020615 AllianceGenome:RGD:1305391
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in nucleosome assembly. Located in dendrite and neuronal cell body. Orthologous to human NAP1L4 (nucleosome assembly protein 1 like 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 571.3), Heart (RPKM 541.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nap1l4 in Genome Data Viewer
    Location:
    1q42
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (208139105..208175597, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (198709697..198746093, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216715352..216751742, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22, member 18 Neighboring gene pleckstrin homology-like domain, family A, member 2 Neighboring gene small nucleolar RNA, H/ACA box 54 Neighboring gene cysteinyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC134483952 Neighboring gene transfer RNA valine (anticodon AAC) 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cellular expression and localization of DGKζ-interacting NAP1-like proteins in the brain and functional implications under hypoxic stress. Takahashi N, et al. Histochem Cell Biol, 2014 Nov. PMID 24893663
    2. Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. Rodriguez P, et al. Genomics, 1997 Sep 15. PMID 9325046
    3. Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells. Barral S, et al. Mol Cell, 2017 Apr 6. PMID 28366643
    4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    5. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. Benleulmi-Chaachoua A, et al. J Pineal Res, 2016 Jan. PMID 26514267

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleosome assembly protein 1-like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012170.1 → NP_001012170.1  nucleosome assembly protein 1-like 4

      See identical proteins and their annotated locations for NP_001012170.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085801
      UniProtKB/Swiss-Prot
      Q5U2Z3
      UniProtKB/TrEMBL
      A0A8L2RA59, A6HYC3
      Related
      ENSRNOP00000051745.5, ENSRNOT00000054862.6
      Conserved Domains (1) summary
      pfam00956
      Location:67 → 337
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      208139105..208175597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230823.5 → XP_006230885.1  nucleosome assembly protein 1-like 4 isoform X1

      See identical proteins and their annotated locations for XP_006230885.1

      UniProtKB/Swiss-Prot
      Q5U2Z3
      UniProtKB/TrEMBL
      A0A8L2RA59, A6HYC3
      Conserved Domains (1) summary
      pfam00956
      Location:67 → 337
      NAP; Nucleosome assembly protein (NAP)

    2. XM_006230824.5 → XP_006230886.1  nucleosome assembly protein 1-like 4 isoform X1

      See identical proteins and their annotated locations for XP_006230886.1

      UniProtKB/Swiss-Prot
      Q5U2Z3
      UniProtKB/TrEMBL
      A0A8L2RA59, A6HYC3
      Conserved Domains (1) summary
      pfam00956
      Location:67 → 337
      NAP; Nucleosome assembly protein (NAP)

    3. XM_063268048.1 → XP_063124118.1  nucleosome assembly protein 1-like 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2Z3
      UniProtKB/TrEMBL
      A6HYC3
      Related
      ENSRNOP00000093428.2, ENSRNOT00000102937.2

    4. XM_063268066.1 → XP_063124136.1  nucleosome assembly protein 1-like 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2Z3
      UniProtKB/TrEMBL
      A6HYC3

    5. XM_063268072.1 → XP_063124142.1  nucleosome assembly protein 1-like 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2Z3
      UniProtKB/TrEMBL
      A6HYC3

    6. XM_063268061.1 → XP_063124131.1  nucleosome assembly protein 1-like 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2Z3
      UniProtKB/TrEMBL
      A6HYC3

    7. XM_063268046.1 → XP_063124116.1  nucleosome assembly protein 1-like 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2Z3
      UniProtKB/TrEMBL
      A6HYC3

    8. XM_063268053.1 → XP_063124123.1  nucleosome assembly protein 1-like 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2Z3
      UniProtKB/TrEMBL
      A6HYC3

    9. XM_063268082.1 → XP_063124152.1  nucleosome assembly protein 1-like 4 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHZ2, A6HYC4

    10. XM_063268091.1 → XP_063124161.1  nucleosome assembly protein 1-like 4 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHZ2, A6HYC4

    11. XM_063268100.1 → XP_063124170.1  nucleosome assembly protein 1-like 4 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHZ2, A6HYC4
      Related
      ENSRNOP00000075200.3, ENSRNOT00000087961.3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2Z3.1 GenPept UniProtKB/Swiss-Prot:Q5U2Z3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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