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    Dnajb13 DnaJ heat shock protein family (Hsp40) member B13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308857, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnajb13provided by RGD
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B13provided by RGD
    Primary source
    RGD:1359131
    See related
    EnsemblRapid:ENSRNOG00000017975 AllianceGenome:RGD:1359131
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tsarg1
    Summary
    Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in axonemal central apparatus assembly and chaperone cofactor-dependent protein refolding. Predicted to be located in axoneme; sperm flagellum; and sperm head-tail coupling apparatus. Predicted to be part of radial spoke. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 34. Orthologous to human DNAJB13 (DnaJ heat shock protein family (Hsp40) member B13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 123.5), Spleen (RPKM 32.6) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnajb13 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (164260716..164275172, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154848586..154863042, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165515718..165530163, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncoupling protein 3 Neighboring gene uncoupling protein 2 Neighboring gene uncharacterized LOC103691200 Neighboring gene uncharacterized LOC120099893 Neighboring gene cytochrome c oxidase assembly factor 4 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of a novel rat gene Tsarg1, a member of the DnaJ/HSP40 protein family. Yang HM, et al. DNA Seq, 2005 Jun. PMID 16147871
    2. Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility. El Khouri E, et al. Am J Hum Genet, 2016 Aug 4. PMID 27486783, Free PMC Article
    3. DNAJB13, a type II HSP40 family member, localizes to the spermatids and spermatozoa during mouse spermatogenesis. Li W, et al. BMC Dev Biol, 2014 Sep 19. PMID 25233908, Free PMC Article
    4. Essential role for SUN5 in anchoring sperm head to the tail. Shang Y, et al. Elife, 2017 Sep 25. PMID 28945193, Free PMC Article
    5. A heat-shock protein 40, DNAJB13, is an axoneme-associated component in mouse spermatozoa. Guan J, et al. Mol Reprod Dev, 2008 Sep. PMID 18247331

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tsarg1 is specifically expressed in rat testis, which probably inhibits rat testis spermatogenic cell apoptosis
      Title: Molecular cloning of a novel rat gene Tsarg1, a member of the DnaJ/HSP40 protein family.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonemal central apparatus assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of radial spoke ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm head-tail coupling apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily B member 13
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 13
    DnaJ (Hsp40) related, subfamily B, member 13
    testis spermatogenesis apoptosis-related protein 1
    testis spermatogenesis apoptosis-related protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005885.2 → NP_001005885.1  dnaJ homolog subfamily B member 13

      See identical proteins and their annotated locations for NP_001005885.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098002
      UniProtKB/TrEMBL
      A6I6P4, B3LEP3, Q5YKV6
      Related
      ENSRNOP00000024256.5, ENSRNOT00000024256.7
      Conserved Domains (3) summary
      cd10747
      Location:138 → 302
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 312
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:4 → 65
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      164260716..164275172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229766.3 → XP_006229828.1  dnaJ homolog subfamily B member 13 isoform X1

      UniProtKB/TrEMBL
      A6I6P4
      Conserved Domains (3) summary
      cd10747
      Location:137 → 301
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 311
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:4 → 64
      DnaJ; DnaJ domain

    2. XM_063262811.1 → XP_063118881.1  dnaJ homolog subfamily B member 13 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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