Rasgrp4 RAS guanyl releasing protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rasgrp4provided by RGD
Official Full Name: RAS guanyl releasing protein 4provided by RGD
Primary source: RGD:620476
See related: EnsemblRapid:ENSRNOG00000033744 AllianceGenome:RGD:620476
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable diacylglycerol binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including Ras protein signal transduction; antibacterial innate immune response; and positive regulation of natural killer cell mediated immunity. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human RASGRP4 (RAS guanyl releasing protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 27.5), Lung (RPKM 25.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (93560513..93580321)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (84433033..84452841)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (88078350..88094331)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RasGRP-4 is aberrantly expressed in fibroblast-like synoviocytes and helps regulate their growth.
Title: Ras guanine nucleotide-releasing protein 4 is aberrantly expressed in the fibroblast-like synoviocytes of patients with rheumatoid arthritis and controls their proliferation.
Cloning of Ras guanine nucleotide releasing protein 4, and evaluation of its expression in mast cells and their bone marrow progenitors.
Title: Cloning of rat Ras guanine nucleotide releasing protein 4, and evaluation of its expression in rat mast cells and their bone marrow progenitors.
RasGRP4 regulates the expression of prostaglandin D2 in mast cell
Title: RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol binding	ISO Inferred from Sequence Orthology more info
enables diacylglycerol binding	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in antibacterial innate immune response	IEA Inferred from Electronic Annotation more info
involved_in antibacterial innate immune response	ISO Inferred from Sequence Orthology more info
involved_in antibacterial innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of natural killer cell mediated immunity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated immunity	ISS Inferred from Sequence or Structural Similarity more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RAS guanyl-releasing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130824.2 → NP_570837.2 RAS guanyl-releasing protein 4

See identical proteins and their annotated locations for NP_570837.2

Status: PROVISIONAL

Source sequence(s)

AF465263

UniProtKB/Swiss-Prot

Q8R5I3, Q8R5I4

UniProtKB/TrEMBL

F1LMG1

Related

ENSRNOP00000046440.6, ENSRNOT00000048677.6

Conserved Domains (3) summary

cd06224
Location:57 → 172

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:197 → 432

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cl00040
Location:538 → 599

C1; protein kinase C conserved region 1 (C1 domain) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

93560513..93580321

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084122.1 → XP_038940050.1 RAS guanyl-releasing protein 4 isoform X3

UniProtKB/TrEMBL

F1LMG1

Related

ENSRNOP00000088115.1, ENSRNOT00000104105.2

Conserved Domains (3) summary

cd06224
Location:57 → 172

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:197 → 432

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cl00040
Location:538 → 594

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_039084209.2 → XP_038940137.1 RAS guanyl-releasing protein 4 isoform X4

Conserved Domains (2) summary

cd06224
Location:105 → 220

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:245 → 480

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
XM_039084022.2 → XP_038939950.1 RAS guanyl-releasing protein 4 isoform X1

UniProtKB/TrEMBL

F1LMG1

Related

ENSRNOP00000107351.1, ENSRNOT00000127958.1

Conserved Domains (3) summary

cd06224
Location:105 → 220

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:245 → 480

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cl00040
Location:586 → 647

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_039084068.2 → XP_038939996.1 RAS guanyl-releasing protein 4 isoform X2

UniProtKB/TrEMBL

F1LMG1

Conserved Domains (3) summary

cd06224
Location:105 → 220

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:245 → 480

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cl00040
Location:586 → 642

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_039084266.2 → XP_038940194.1 RAS guanyl-releasing protein 4 isoform X5

UniProtKB/TrEMBL

A6J9N0

Conserved Domains (2) summary

smart00147
Location:76 → 311

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cl00040
Location:417 → 478

C1; protein kinase C conserved region 1 (C1 domain) superfamily