nudE nudE [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nudEprovided by FlyBase
Official Full Name: nudEprovided by FlyBase
Primary source: FLYBASE:FBgn0036059
Locus tag: Dmel_CG8104
See related: AllianceGenome:FB:FBgn0036059
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8104; Dmel\CG8104; DnudE; NudE
Summary: Predicted to enable microtubule binding activity. Involved in several processes, including neuron projection morphogenesis; nuclear chromosome segregation; and oogenesis. Located in several cellular components, including kinetochore; spindle; and spindle envelope. Is expressed in germline cell; organism; pole plasm; and primordial germ cell. Used to study Rubinstein-Taybi syndrome. Human ortholog(s) of this gene implicated in lissencephaly 4. Orthologous to human NDE1 (nudE neurodevelopment protein 1) and NDEL1 (nudE neurodevelopment protein 1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 67D1-67D1; 3-32 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9899241..9903031)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9891803..9896131)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Khc73 stalk/14-3-3/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
Title: A NudE/14-3-3 pathway coordinates dynein and the kinesin Khc73 to position the mitotic spindle.
A general role of Lis-1/NudE, Dynein and microtubules, in cell-on-cell migration, is reported.
Title: Microtubules and Lis-1/NudE/dynein regulate invasive cell-on-cell migration in Drosophila.
Intrinsic disorder in dynein intermediate chain modulates its interactions with NudE and dynactin.
Title: Intrinsic disorder in dynein intermediate chain modulates its interactions with NudE and dynactin.
Data suggets that NudE regulates dynein function at the kinetochore.
Title: Roles of the Drosophila NudE protein in kinetochore function and centrosome migration.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in centrosome duplication	ISS Inferred from Sequence or Structural Similarity more info
involved_in centrosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in centrosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of chromosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic centrosome separation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleus localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle envelope	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole centrosome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nudE

Names: CG8104-PA; CG8104-PB; CG8104-PC; CG8104-PD; CG8104-PF; nudE-PA; nudE-PB; nudE-PC; nudE-PD; nudE-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9899241..9903031

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300088.1 → NP_001287017.1 nudE, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287017.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JNQ0

Conserved Domains (1) summary

pfam04880
Location:129 → 177

NUDE_C; NUDE protein, C-terminal conserved region
NM_001104098.2 → NP_001097568.1 nudE, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097568.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JNQ0

Conserved Domains (1) summary

pfam04880
Location:129 → 177

NUDE_C; NUDE protein, C-terminal conserved region
NM_140116.3 → NP_648373.1 nudE, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648373.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95RM2, Q9VT70

Related

FBpp0076073

Conserved Domains (1) summary

pfam04880
Location:129 → 177

NUDE_C; NUDE protein, C-terminal conserved region
NM_001104099.3 → NP_001097569.1 nudE, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097569.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JNQ1

Conserved Domains (1) summary

pfam04880
Location:129 → 177

NUDE_C; NUDE protein, C-terminal conserved region
NM_001144458.3 → NP_001137930.1 nudE, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137930.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z0G0

Conserved Domains (1) summary

pfam04880
Location:129 → 177

NUDE_C; NUDE protein, C-terminal conserved region