Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a3provided by MGI
Official Full Name: solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3provided by MGI
Primary source: MGI:MGI:1353498
See related: Ensembl:ENSMUSG00000061904 AllianceGenome:MGI:1353498
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PTP; Phc; 5730556H19Rik
Summary: Predicted to enable phosphate transmembrane transporter activity and phosphate:proton symporter activity. Predicted to be involved in phosphate ion transmembrane transport. Located in mitochondrial inner membrane and myelin sheath. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human SLC25A3 (solute carrier family 25 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 904.7), duodenum adult (RPKM 787.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C2; 10 45.6 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (90952436..90959902, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (91116574..91124046, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.
Title: METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.
SLC25A3 negatively regulates NLRP3 inflammasome activation by restricting the function of NLRP3.
Title: SLC25A3 negatively regulates NLRP3 inflammasome activation by restricting the function of NLRP3.
An implication of the mitochondrial carrier SLC25A3 as an oxidative stress modulator in NAFLD.
Title: An implication of the mitochondrial carrier SLC25A3 as an oxidative stress modulator in NAFLD.
Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome.
Title: Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome.
SLC25A3 is a mitochondrial copper transporter.
Title: The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis.
The mitochondrial PiC is not a critical component of the MPT pore.
Title: Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition.
The results indicated that miR-141 can regulate Slc25a3 protein expression in the diabetic heart. Further, diabetes-induced miRNA changes may influence mitochondrial proteomes and functional processes such as mitochondrial ATP production.
Title: miR-141 as a regulator of the mitochondrial phosphate carrier (Slc25a3) in the type 1 diabetic heart.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB224897 (e-PCR)
- UniSTS:208595

D10Mit302 (e-PCR), detects polymorphism
- UniSTS:126207

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables phosphate:proton symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial phosphate ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	HDA more info	PubMed
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed

General protein information

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Preferred Names: solute carrier family 25 member 3

Names: phosphate carrier protein, mitochondrial; phosphate transport protein; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001428746.1 → NP_001415675.1 solute carrier family 25 member 3 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC140410

UniProtKB/TrEMBL

G5E902, Q3THU8, Q3U995, Q3UB63
NM_001428747.1 → NP_001415676.1 solute carrier family 25 member 3 isoform 3

Status: VALIDATED

Source sequence(s)

AC140410

UniProtKB/TrEMBL

Q3THU8
NM_133668.5 → NP_598429.1 solute carrier family 25 member 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_598429.1

Status: VALIDATED

Source sequence(s)

AC140410

Consensus CDS

CCDS24121.1

UniProtKB/Swiss-Prot

Q542V7, Q8VEM8

UniProtKB/TrEMBL

Q3THU8, Q3U995, Q3UB63

Related

ENSMUSP00000075987.7, ENSMUST00000076694.13

Conserved Domains (2) summary

PTZ00169
Location:66 → 332

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:59 → 147

Mito_carr; Mitochondrial carrier protein

RNA

NR_190487.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC140410

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

90952436..90959902 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513371.5 → XP_006513434.1 solute carrier family 25 member 3 isoform X1

Related

ENSMUSP00000127098.2, ENSMUST00000170810.8

Conserved Domains (1) summary

pfam00153
Location:60 → 146

Mito_carr; Mitochondrial carrier protein