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    Lhfpl2 lipoma HMGIC fusion partner-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 218454, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lhfpl2provided by MGI
    Official Full Name
    lipoma HMGIC fusion partner-like 2provided by MGI
    Primary source
    MGI:MGI:2145236
    See related
    Ensembl:ENSMUSG00000045312 AllianceGenome:MGI:2145236
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    vgim; mKIAA0206; 6030465B15
    Summary
    Involved in development of primary female sexual characteristics; development of primary male sexual characteristics; and positive regulation of fertilization. Predicted to be active in membrane. Is expressed in several structures, including central nervous system; hemolymphoid system gland; liver; reproductive system; and tail unsegmented mesenchyme. Orthologous to human LHFPL2 (LHFPL tetraspan subfamily member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 19.7), limb E14.5 (RPKM 15.8) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lhfpl2 in Genome Data Viewer
    Location:
    13 C3; 13 49.03 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (94193659..94331918)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (94057152..94195410)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35297 Neighboring gene predicted gene, 24737 Neighboring gene STARR-seq mESC enhancer starr_35299 Neighboring gene STARR-seq mESC enhancer starr_35300 Neighboring gene cytochrome c, pseudogene 3 Neighboring gene predicted gene, 57596 Neighboring gene secretory carrier membrane protein 1 Neighboring gene STARR-seq mESC enhancer starr_35303 Neighboring gene predicted gene, 32089

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel function of LHFPL2 in female and male distal reproductive tract development. Zhao F, et al. Sci Rep, 2016 Mar 11. PMID 26964900, Free PMC Article
    2. Mutation discovery in mice by whole exome sequencing. Fairfield H, et al. Genome Biol, 2011 Sep 14. PMID 21917142, Free PMC Article
    3. Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro. Chal J, et al. Development, 2018 Mar 19. PMID 29555813
    4. Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Fairfield H, et al. Genome Res, 2015 Jul. PMID 25917818, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Spontaneous (1) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in development of primary female sexual characteristics IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in development of primary male sexual characteristics IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    LHFPL tetraspan subfamily member 2 protein
    Names
    lipoma HMGIC fusion partner-like 2 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172589.2 → NP_766177.1  LHFPL tetraspan subfamily member 2 protein

      See identical proteins and their annotated locations for NP_766177.1

      Status: PROVISIONAL

      Source sequence(s)
      AK087506
      Consensus CDS
      CCDS26692.1
      UniProtKB/Swiss-Prot
      Q8BGA2
      Related
      ENSMUSP00000062239.2, ENSMUST00000054274.8
      Conserved Domains (1) summary
      cl21598
      Location:9 → 198
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      94193659..94331918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247231.2 → XP_030103091.1  LHFPL tetraspan subfamily member 2 protein isoform X2

    2. XM_011244639.4 → XP_011242941.1  LHFPL tetraspan subfamily member 2 protein isoform X1

      See identical proteins and their annotated locations for XP_011242941.1

      UniProtKB/Swiss-Prot
      Q8BGA2
      Conserved Domains (1) summary
      cl21598
      Location:9 → 198
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    3. XM_036158012.1 → XP_036013905.1  LHFPL tetraspan subfamily member 2 protein isoform X1

      UniProtKB/Swiss-Prot
      Q8BGA2
      Conserved Domains (1) summary
      cl21598
      Location:9 → 198
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    4. XM_011244640.3 → XP_011242942.1  LHFPL tetraspan subfamily member 2 protein isoform X1

      See identical proteins and their annotated locations for XP_011242942.1

      UniProtKB/Swiss-Prot
      Q8BGA2
      Conserved Domains (1) summary
      cl21598
      Location:9 → 198
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    5. XM_036158013.1 → XP_036013906.1  LHFPL tetraspan subfamily member 2 protein isoform X1

      UniProtKB/Swiss-Prot
      Q8BGA2
      Conserved Domains (1) summary
      cl21598
      Location:9 → 198
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    6. XM_036158014.1 → XP_036013907.1  LHFPL tetraspan subfamily member 2 protein isoform X1

      UniProtKB/Swiss-Prot
      Q8BGA2
      Conserved Domains (1) summary
      cl21598
      Location:9 → 198
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    7. XM_011244641.4 → XP_011242943.1  LHFPL tetraspan subfamily member 2 protein isoform X1

      See identical proteins and their annotated locations for XP_011242943.1

      UniProtKB/Swiss-Prot
      Q8BGA2
      Conserved Domains (1) summary
      cl21598
      Location:9 → 198
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    8. XM_011244642.4 → XP_011242944.1  LHFPL tetraspan subfamily member 2 protein isoform X1

      See identical proteins and their annotated locations for XP_011242944.1

      UniProtKB/Swiss-Prot
      Q8BGA2
      Conserved Domains (1) summary
      cl21598
      Location:9 → 198
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    9. XM_011244643.4 → XP_011242945.1  LHFPL tetraspan subfamily member 2 protein isoform X1

      See identical proteins and their annotated locations for XP_011242945.1

      UniProtKB/Swiss-Prot
      Q8BGA2
      Related
      ENSMUSP00000113468.2, ENSMUST00000121618.2
      Conserved Domains (1) summary
      cl21598
      Location:9 → 198
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGA2.1 GenPept UniProtKB/Swiss-Prot:Q8BGA2

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