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    Glra4 glycine receptor, alpha 4 subunit [ Mus musculus (house mouse) ]

    Gene ID: 14657, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Glra4provided by MGI
    Official Full Name
    glycine receptor, alpha 4 subunitprovided by MGI
    Primary source
    MGI:MGI:95750
    See related
    Ensembl:ENSMUSG00000018595 AllianceGenome:MGI:95750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables extracellularly glycine-gated chloride channel activity. Involved in chloride transmembrane transport and response to amino acid. Located in plasma membrane. Is active in glycinergic synapse and postsynaptic specialization membrane. Is expressed in brain. Orthologous to human GLRA4 (glycine receptor alpha 4 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Glra4 in Genome Data Viewer
    Location:
    X F1; X 59.1 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135655107..135680935, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136754515..136780141, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39536 Neighboring gene transcription elongation factor A (SII)-like 1 Neighboring gene STARR-seq mESC enhancer starr_47978 Neighboring gene STARR-positive B cell enhancer ABC_E3262 Neighboring gene mortality factor 4 like 2 Neighboring gene STARR-positive B cell enhancer ABC_E11056 Neighboring gene cDNA sequence BC065397 Neighboring gene predicted gene, 54085 Neighboring gene STARR-seq mESC enhancer starr_47979 Neighboring gene proteolipid protein (myelin) 1 Neighboring gene RAB9B, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Glycine receptors containing the alpha4 subunit in the embryonic sympathetic nervous system, spinal cord and male genital ridge. Harvey RJ, et al. Eur J Neurosci, 2000 Mar. PMID 10762330
    2. Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit. Heinze L, et al. J Comp Neurol, 2007 Feb 1. PMID 17154252
    3. Native glycine receptor subtypes and their physiological roles. Lynch JW. Neuropharmacology, 2009 Jan. PMID 18721822
    4. Glycinergic input of widefield, displaced amacrine cells of the mouse retina. Majumdar S, et al. J Physiol, 2009 Aug 1. PMID 19528249, Free PMC Article
    5. Developmental regulation of glycine receptors at efferent synapses of the murine cochlea. Buerbank S, et al. Histochem Cell Biol, 2011 Oct. PMID 21850450

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The distinct developmental regulation of GlyRalpha4 in the murine cochlea advocates a contribution of these chloride channels to efferent olivocochlear innervation.
      Title: Developmental regulation of glycine receptors at efferent synapses of the murine cochlea.
    2. Glycine receptors (GlyRs) of group II cells are dominated by the alpha2 subunit; GlyRs of ON-starburst amacrine cells appear to be dominated by the alpha4 subunit.
      Title: Glycinergic input of widefield, displaced amacrine cells of the mouse retina.
    3. The alpha4 subunit was localized in the inner plexiform layer (IPL) in brightly fluorescent puncta, which represent postsynaptically clustered glycine receptors.
      Title: Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130223, MGC130237

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellularly glycine-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to amino acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glycinergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycine receptor subunit alpha-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425633.1 → NP_001412562.1  glycine receptor subunit alpha-4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL671887

    2. NM_001425634.1 → NP_001412563.1  glycine receptor subunit alpha-4 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL671887

    3. NM_001425635.1 → NP_001412564.1  glycine receptor subunit alpha-4 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL671887

    4. NM_001425636.1 → NP_001412565.1  glycine receptor subunit alpha-4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL671887
      UniProtKB/TrEMBL
      Q2TB05

    5. NM_010297.3 → NP_034427.2  glycine receptor subunit alpha-4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034427.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL671887
      Consensus CDS
      CCDS53195.1
      UniProtKB/Swiss-Prot
      A2AEA9, Q45V76, Q61603, Q8VHF3
      UniProtKB/TrEMBL
      Q2TB05
      Related
      ENSMUSP00000018739.5, ENSMUST00000018739.5
      Conserved Domains (1) summary
      TIGR00860
      Location:9 → 444
      LIC; Cation transporter family protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      135655107..135680935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61603.3 GenPept UniProtKB/Swiss-Prot:Q61603

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