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    Acad12 acyl-Coenzyme A dehydrogenase family, member 12 [ Mus musculus (house mouse) ]

    Gene ID: 338350, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Acad12provided by MGI
    Official Full Name
    acyl-Coenzyme A dehydrogenase family, member 12provided by MGI
    Primary source
    MGI:MGI:2443320
    See related
    Ensembl:ENSMUSG00000042647 AllianceGenome:MGI:2443320
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9330129D05Rik
    Summary
    Predicted to enable acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in mitochondrion. Orthologous to human ACAD10 (acyl-CoA dehydrogenase family member 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in heart adult (RPKM 19.6), kidney adult (RPKM 16.2) and 17 other tissues See more
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    Genomic context

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    See Acad12 in Genome Data Viewer
    Location:
    5 F; 5 61.87 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121736340..121757001, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121598277..121618938, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14259 Neighboring gene MAP kinase-activated protein kinase 5 Neighboring gene STARR-positive B cell enhancer ABC_E9092 Neighboring gene STARR-positive B cell enhancer ABC_E11301 Neighboring gene STARR-seq mESC enhancer starr_14260 Neighboring gene aldehyde dehydrogenase 2, mitochondrial Neighboring gene STARR-seq mESC enhancer starr_14261 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 10 Neighboring gene BRCA1 associated protein Neighboring gene ataxin 2 Neighboring gene STARR-seq mESC enhancer starr_14264 Neighboring gene SH2B adaptor protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. Grose JH, et al. PLoS One, 2015. PMID 26465331, Free PMC Article
    2. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    acyl-Coenzyme A dehydrogenase family, member 10-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178799.3 → NP_848914.2  acyl-Coenzyme A dehydrogenase family, member 10-like

      See identical proteins and their annotated locations for NP_848914.2

      Status: VALIDATED

      Source sequence(s)
      AK033963, AK080793, BB352084, BB643798
      Consensus CDS
      CCDS51642.1
      UniProtKB/TrEMBL
      D3Z7X0
      Related
      ENSMUSP00000046497.7, ENSMUST00000041252.13
      Conserved Domains (2) summary
      TIGR02247
      Location:41 → 58
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase
      cl09933
      Location:154 → 542
      ACAD; Acyl-CoA dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      121736340..121757001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248231.1 → XP_011246533.1  acyl-Coenzyme A dehydrogenase family, member 10-like isoform X1

      See identical proteins and their annotated locations for XP_011246533.1

      UniProtKB/TrEMBL
      D3Z7X0
      Conserved Domains (2) summary
      TIGR02247
      Location:41 → 58
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase
      cl09933
      Location:154 → 542
      ACAD; Acyl-CoA dehydrogenase
    Nucleotide Protein Strain
    Heading Accession and Version

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