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    Rras2 related RAS viral (r-ras) oncogene 2 [ Mus musculus (house mouse) ]

    Gene ID: 66922, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rras2provided by MGI
    Official Full Name
    related RAS viral (r-ras) oncogene 2provided by MGI
    Primary source
    MGI:MGI:1914172
    See related
    Ensembl:ENSMUSG00000055723 AllianceGenome:MGI:1914172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TC21; 2610016H24Rik
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within Ras protein signal transduction and positive regulation of Schwann cell migration. Predicted to be located in Golgi membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; cerebral cortex; lung; metanephros; and thymus primordium. Human ortholog(s) of this gene implicated in Noonan syndrome 12. Orthologous to human RRAS2 (RAS related 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 16.6), duodenum adult (RPKM 9.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rras2 in Genome Data Viewer
    Location:
    7 F1; 7 59.29 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (113646017..113717016, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (114046782..114117781, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5600 Neighboring gene spondin 1, (f-spondin) extracellular matrix protein Neighboring gene STARR-seq mESC enhancer starr_19921 Neighboring gene STARR-seq mESC enhancer starr_19922 Neighboring gene STARR-positive B cell enhancer ABC_E6588 Neighboring gene STARR-positive B cell enhancer ABC_E8937 Neighboring gene predicted gene, 51454 Neighboring gene STARR-positive B cell enhancer ABC_E9298 Neighboring gene predicted gene, 53365 Neighboring gene STARR-seq mESC enhancer starr_19925 Neighboring gene STARR-seq mESC enhancer starr_19926 Neighboring gene STARR-positive B cell enhancer ABC_E4966 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:121419678-121419787 Neighboring gene coatomer protein complex, subunit beta 1 Neighboring gene proteasome subunit alpha 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System. Garcia-Martin G, et al. Int J Mol Sci, 2022 Jan 17. PMID 35055164, Free PMC Article
    2. Absence of R-Ras1 and R-Ras2 causes mitochondrial alterations that trigger axonal degeneration in a hypomyelinating disease model. Alcover-Sanchez B, et al. Glia, 2021 Mar. PMID 33010069
    3. Essential function for the GTPase TC21 in homeostatic antigen receptor signaling. Delgado P, et al. Nat Immunol, 2009 Aug. PMID 19561613
    4. T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis. Martínez-Martín N, et al. Immunity, 2011 Aug 26. PMID 21820331, Free PMC Article
    5. Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease. Larive RM, et al. Nat Commun, 2014 May 14. PMID 24826867

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors.
      Title: A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors.
    2. Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia.
      Title: Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia.
    3. R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System.
      Title: R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System.
    4. An analysis of the TCR repertoire shows alterations that mostly affect the TCRalpha variable (TRAV) locus with specific VJ combinations and CDR3alpha sequences that are absent in Rras2(-/-) mice, suggesting their involvement in autoimmunity
      Title: RRAS2 shapes the TCR repertoire by setting the threshold for negative selection.
    5. Mice lacking R-Ras1 and/or R-Ras2 show a diminished oligodendrocytes population with a higher proportion of immature oligodendrocytes, explaining the observed hypomyelination
      Title: R-Ras1 and R-Ras2 Are Essential for Oligodendrocyte Differentiation and Survival for Correct Myelination in the Central Nervous System.
    6. SIRT6, a sirtuin with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.
      Title: SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.
    7. The RLIP76/R-Ras/ARNO complex localizes to recycling endosomes.RLIP76 is a linker protein connecting R-Ras to ARNO.
      Title: RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.
    8. R-Ras2 has a role in both primary breast tumorigenesis and the late metastatic steps of cancer cells in the lung parenchyma.
      Title: Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease.
    9. findings reveal R-Ras2 as a critical regulator of TGF-beta signaling in vivo.
      Title: In vivo regulation of TGF-β by R-Ras2 revealed through loss of the RasGAP protein NF1.
    10. Data indicate that RRas2(-/-) mice show no major alterations in viability, growth rates, cardiovascular parameters, or fertility.
      Title: The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of Schwann cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of Schwann cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein R-Ras2
    Names
    related RAS viral (r-ras) oncogene homolog 2
    NP_080122.2
    XP_017167728.1
    XP_036009261.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025846.2 → NP_080122.2  ras-related protein R-Ras2

      See identical proteins and their annotated locations for NP_080122.2

      Status: VALIDATED

      Source sequence(s)
      AK003733, AK011419, AK078870, BX524069
      Consensus CDS
      CCDS21758.1
      UniProtKB/Swiss-Prot
      P62071, Q3TA79, Q8C5D1, Q9D0H6
      Related
      ENSMUSP00000069752.6, ENSMUST00000069449.7
      Conserved Domains (1) summary
      cd04145
      Location:13 → 176
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      113646017..113717016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153368.1 → XP_036009261.1  ras-related protein R-Ras2 isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:1 → 99
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_017312239.2 → XP_017167728.1  ras-related protein R-Ras2 isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:1 → 99
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62071.1 GenPept UniProtKB/Swiss-Prot:P62071

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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