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    Chodl chondrolectin [ Mus musculus (house mouse) ]

    Gene ID: 246048, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Chodlprovided by MGI
    Official Full Name
    chondrolectinprovided by MGI
    Primary source
    MGI:MGI:2179069
    See related
    Ensembl:ENSMUSG00000022860 AllianceGenome:MGI:2179069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MT75; PRED12; 3110074E07Rik
    Summary
    Predicted to enable carbohydrate binding activity. Acts upstream of or within regulation of neuron projection development. Predicted to be located in centrosome; cytosol; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and respiratory system. Orthologous to human CHODL (chondrolectin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 14.3), bladder adult (RPKM 7.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Chodl in Genome Data Viewer
    Location:
    16 C3.1; 16 45.39 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (78727729..78748624)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (78930841..78951736)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41311 Neighboring gene predicted gene, 24861 Neighboring gene RIKEN cDNA 4930570E03 gene Neighboring gene STARR-seq mESC enhancer starr_41312 Neighboring gene STARR-seq mESC enhancer starr_41313 Neighboring gene STARR-seq mESC enhancer starr_41314 Neighboring gene STARR-seq mESC enhancer starr_41315 Neighboring gene transmembrane protease, serine 15 Neighboring gene STARR-seq mESC enhancer starr_41316 Neighboring gene STARR-seq mESC enhancer starr_41317 Neighboring gene STARR-seq mESC enhancer starr_41318 Neighboring gene STARR-seq mESC enhancer starr_41319 Neighboring gene aldo-keto reductase family 1, member D1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of chondrolectin (Chodl), a novel C-type lectin predominantly expressed in muscle cells. Weng L, et al. Gene, 2003 Apr 10. PMID 12711387
    2. The cytoplasmic domain of chondrolectin interacts with the beta-subunit of Rab geranylgeranyl transferase. Claessens A, et al. Cell Mol Biol Lett, 2008. PMID 18161010, Free PMC Article
    3. Molecular cloning and characterization of human chondrolectin, a novel type I transmembrane protein homologous to C-type lectins. Weng L, et al. Genomics, 2002 Jul. PMID 12079284
    4. The organization of submodality-specific touch afferent inputs in the vibrissa column. Sakurai K, et al. Cell Rep, 2013 Oct 17. PMID 24120861, Free PMC Article
    5. Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as markers for fast motor neurons and partition cells. Enjin A, et al. J Comp Neurol, 2010 Jun 15. PMID 20437528

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation.
      Title: Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation.
    2. Chodl expression exacerbates reduction in cell viability owing to low Smn levels.
      Title: Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy.
    3. we present evidence that chondrolectin (Chodl) is expressed by fast motor neurons and that estrogen-related receptor beta (ERRbeta) is a candidate marker for slow motor neurons in the spinal cord
      Title: Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as markers for fast motor neurons and partition cells.
    4. The function of chodl was investigated by searching for its protein interaction partners.
      Title: The cytoplasmic domain of chondrolectin interacts with the beta-subunit of Rab geranylgeranyl transferase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables hyaluronic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chondrolectin
    Names
    transmembrane protein MT75

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362555.1 → NP_001349484.1  chondrolectin isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC114925, AC161815
      Consensus CDS
      CCDS88954.1
      UniProtKB/TrEMBL
      B7ZMQ3, F2Z3Y6
      Related
      ENSMUSP00000156041.2, ENSMUST00000232415.2
      Conserved Domains (1) summary
      cl02432
      Location:28 → 180
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    2. NM_139134.5 → NP_624360.2  chondrolectin isoform 1 precursor

      See identical proteins and their annotated locations for NP_624360.2

      Status: VALIDATED

      Source sequence(s)
      AC114925, AC161815
      Consensus CDS
      CCDS28279.1
      UniProtKB/Swiss-Prot
      Q3US20, Q8BVU2, Q8VI31, Q9CXM0
      UniProtKB/TrEMBL
      F2Z3Y6
      Related
      ENSMUSP00000023568.8, ENSMUST00000023568.14
      Conserved Domains (1) summary
      cl02432
      Location:28 → 180
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      78727729..78748624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523030.4 → XP_006523093.1  chondrolectin isoform X1

      See identical proteins and their annotated locations for XP_006523093.1

      UniProtKB/TrEMBL
      F2Z3Y6
      Related
      ENSMUSP00000063961.7, ENSMUST00000069148.13
      Conserved Domains (1) summary
      cl02432
      Location:28 → 180
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    2. XM_006523031.4 → XP_006523094.1  chondrolectin isoform X2

      UniProtKB/TrEMBL
      F2Z3Y6
      Conserved Domains (1) summary
      cl02432
      Location:28 → 180
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    3. XM_006523032.3 → XP_006523095.1  chondrolectin isoform X3

      UniProtKB/TrEMBL
      F2Z3Y6
      Conserved Domains (1) summary
      cl02432
      Location:28 → 180
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXM0.3 GenPept UniProtKB/Swiss-Prot:Q9CXM0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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